摘要
目的探讨西酞普兰治疗癫痫伴发抑郁障碍的疗效和安全性。方法收集40例符合癫痫伴发抑郁障碍的患者,在维持原抗癫痫药物的治疗基础上,辅助给予西酞普兰治疗,疗程8周。分别于治疗后2、4、6、8周采用汉密尔顿抑郁量表(HAMD)评定疗效,同时监测各种不良反应。结果 40例患者经西酞普兰治疗后HAMD评分均有不同程度的下降,治疗前后评分比较有统计学差异,且副反应较轻,无严重不良反应发生。结论西酞普兰治疗癫痫伴发抑郁障碍既有效又安全。
Objective To investigate the safety and efficacy of citalopram in treatment of depression in patients with epilepsy. Methods Forty depressive patients with epilepsy on antiepileptic drugs took part in the study. All patients were given citalopram for 8 weeks. Efficacy was evaluated in according to Hamilton Depression Rating Scale and clinical adverse reaction was monitored at 2,4, 6,8 weekends. Results Of the 40 patients,the scores of Hamilton Depression Rating Scale were all decreased in differently degree. They are statistics variance in scores of prior-treatment and post-treatment. Adverse reactions were comparatively light, severity adverse reactions were not happened. Conclusion Treatment with citalopram were effective and safety to depressive oatients with epilepsy.
出处
《中国现代医生》
2011年第9期53-54,共2页
China Modern Doctor
关键词
癫痫
抑郁
西酞普兰
Epilepsy
Depression
Citalopram
