摘要
目的:系统评价感咳双清胶囊治疗急性上呼吸道感染的有效性和安全性。方法:计算机检索CNKI、VIP、CBM、MEDLINE、EMBASE、Cochrane图书馆,纳入有关感咳双清胶囊治疗急性上呼吸道感染的随机对照试验(RCT),参考Cochrane系统评价员手册5.0.1标准进行质量评价,采用RevMan 5.0软件进行数据处理。结果:共纳入6篇RCT,有急性上呼吸道感染患者1 194例。Meta分析结果,总有效率:儿童中,治疗组A1总有效率优于对照组A2,差异有统计学意义[RR=1.15,95%CI(1.08,1.22)];成人中,治疗组A1总有效率优于对照组A2,差异有统计学意义[RR=1.18,95%CI(1.09,1.28)];治疗组B1总有效率与对照组B2间差异无统计学意义[RR=1.02,95%CI(0.94,1.12)]。主要症状缓解率各研究临床异质性大,采用描述性分析。结论:对于儿童,感咳双清胶囊治疗急性上呼吸道感染的总体疗效优于利巴韦林;对于成人,感咳双清胶囊治疗急性上呼吸道感染的总体疗效和主要症状的缓解率优于或不劣于利巴韦林和清感穿心莲片。但仍有待更多大样本、高质量的RCT进一步验证。
OBJECTIVE：To evaluate the clinical efficacy and safety of Ganke shuangqing capsule for acute upper respiratory tract infection.METHODS：All randomized controlled trails（RCTs） of Ganke shuangqing capsule for acute upper respiratory tract infection were searched from CNKI,VIP,CBM,MEDLINE,EMBASE,Cochrane Library.The quality evaluation of the included studies referred to the Cochrane systematic reviews handbook 5.0.1,and RevMan 5.0 software was used for data analysis.RESULTS：6 RCTs involving 1 194 patients with acute upper respiratory tract infection were included.Meta-analyses showed that in children the total effective rate of treatment group A1 was better than control group A2,there was statistically significant difference [RR=1.15,95% CI（1.08,1.22）];in adults the total effective rate of treatment group A1 was better than control group A2,there was statistically significant difference [RR=1.18,95% CI（1.09,1.28）];There was no significant difference in total effective rate between treatment groupB1 and control group B2[RR=1.02,95%CI（0.94,1.12）].The descriptive analysis was used because of clinical heterogeneity of main symptoms remission rate.CONCLUSION：In children,Ganke shuangqing capsule is better than ribavirin in the treatment of acute upper respiratory tract infection;In adults,total effective rate and main symptoms remission rate of Ganke shuangqing capsule for acute upper respiratory tract infection was better than or not inferior to ribavirin and Qinggan chuanxinlian tablets.Large-scale high quality RCTs were required to validate the results.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第15期1419-1422,共4页
China Pharmacy
关键词
感咳双清胶囊
急性上呼吸道感染
系统评价
Ganke shuangqing capsule
Acute upper respiratory tract infection
Systematic review
