摘要
糖尿病与性腺内分泌功能密切相关。一方面糖代谢异常会影响下丘脑-垂体-性腺轴功能,导致患者性激素紊乱进而导致性腺功能减退;另一方面性激素分泌异常与糖尿病发病风险相关,常见的性腺功能减退性疾病,如高促性腺激素型性腺功能减退——Klinefelter综合征、Turner综合征等,低促性腺激素型性腺功能减退——Kallmann综合征、Prader-Willi综合征等患者糖代谢异常的患病率显著增高。性腺疾病和糖尿病之间相互影响的机制尚不十分确切,可能与胰岛素抵抗、肥胖、染色体基因异常、性激素异常有关。临床上针对性腺疾病合并血糖异常的治疗要个体化。
Diabetes is closely related with the gonadal endocrine functions. On one hand, the abnormal glucose metabolism may affect functions of the hypothalamic-pituitary-gonadal axis, which in turn leads to sex hormone disorders and subsequently hypogonadism in both male and female patients;on the other, abnormal secretion of sex hormones is associated with the risk of diabetes. The common hypogonadism diseases, such as hypergonadotropic hypogonadism （Klinefeher syndrom ,Tuner syndrome） and hypogonadotropic hypogonadism （Kallmann syn- drom, Prader-Willi syndrome）, can significantly increase the prevalence of abnormal glucose metabolism. The exact mechanism that underlies interaction between gonadal diseases and diabetes remains unclear, yet it may be associ- ated with insulin resistance, obesity, abnormal chromosome and abnormal secretion of sex hormone. Clinically, individualized treatment with considerations to both gonadal diseases and abnormal glucose should be advisable.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2011年第4期260-262,共3页
Chinese Journal of Practical Internal Medicine
关键词
糖尿病
性腺疾病
性激素
胰岛素抵抗
diabetes
gonadal disorders
sex hormone
insulin resistance
