摘要
目的探讨血浆中脑肭肽前体N末端片断（Nt-ProBNP）和超敏C反应蛋白（hs-CRP）在急性心肌梗死（AMI）后的水平变化,研究其对AMI患者危险分层及预后的评价。方法收集2008年1月至2009年12月收治的单纯AMI患者112例,同期健康对照78例,治疗前后分别测定患者血浆Nt-ProBNP和hs-CRP水平,根据患者心功能状况（killip分级）分为Ⅰ-Ⅳ组,并按轻重归分为死亡组和非死亡组,比较组间Nt-ProBNP和hs-CRP水平的差异。结果 （1）AMI患者的Nt-ProBNP和hs-CRP水平均明显高于对照组;（2）AMI患者治疗前Nt-ProBNP和hs-CRP水平明显高于治疗后;（3）AMI组中killipⅡ-Ⅳ组的Nt-ProBNP和hs-CRP水平高于killipⅠ组;（4）AMI患者死亡组Nt-ProBNP和hs-CRP水平明显高于非死亡组;（5）AMI患者中的Nt-ProBNP和hs-CRP水平正相关。结论血浆Nt-ProBNP和hs-CRP水平的联合监测有助于AMI病情及预后的评估,对AMI的危险分层具有一定的临床指导意义。
Objective To discuss the plasma concentrations of N-terminal probrain natriuretic peptide（Nt-ProBNP） and high sensitivity C-reactive protein（hs-CRP） in patients with acute myocardial infarction（AMI） and estimate its value in the risk classification and prognosis.Methods A total of 112 AMI patients collected from January 2008 to December 2009 were compared with 78 healthy people who were taken as control group.We tested the plasma concentrations of N-terminal pro-brain natriuretic peptide and hs-CRP pretherapy and post-treatment.Patients were divided into four groups according to the cardiac function（degrees of killip） and divided into dead group and non-dead group at the same time.Then we compared the differences of the concentrations of Nt-ProBNP and hs-CRP among all the groups.Results（1）The concentrations of Nt-ProBNP and hs-CRP in AMI were higher than those in control group;（2） The concentrations of Nt-ProBNP and hs-CRP of AMI patients before the treatment were higher than those of AMI patients after the treatment;（3）The concentrations Nt-ProBNP and hs-CRP levels in killipⅡ~Ⅳ groups were all higher than that in killipⅠgroup;（4）The concentrations of Nt-ProBNP and hs-CRP of died group were higher than those in non-died group;（5）The level of Nt-ProBNP had a positive correlation to the level of hs-CRP.Conclusion The combined test on the levels of plasma Nt-ProBNP and hs-CRP will be helpful for detecting and evaluating the prognosis in patients with AMI,and could be instructive to some extent for clinical risk classification of AMI.
出处
《检验医学与临床》
CAS
2011年第7期821-823,825,共4页
Laboratory Medicine and Clinic
关键词
急性心肌梗死
脑钠钛前体N末端片断
超敏C反应蛋白
acute myocardial infarction
N-terminal probrain natriuretic peptide
high sensitivity C-reactive protein
