摘要
目的 探讨口腔扁平苔藓的免疫发病机理。方法 透射电子显微镜。结果 活化的 T 淋巴细胞攻击粘膜上皮细胞; 上皮基底板呈间断性断裂;肥大细胞增生、活化、脱颗粒、溶解; 粘膜固有层淋巴细胞带状浸润,可见淋巴细胞间合作现象; 微血管内皮细胞及周细胞损害; 微血管基底板高度增厚, 显示有免疫沉积物; 粘膜上皮凋亡; 郎格罕细胞变化。结论 进一步证实口腔扁平苔藓是以细胞介导的免疫反应为主。
Objective\ To investigate the immunopathogenesis of oral lichen planus.Method Transmission elecron microscope.Result Activated T lymphocytes attack epithelial cells;basement membrane fragmentation and breakdown;proliferation、activation,degranulation and cytolysis of mast cellular cooperation;damage of the microvascular endothelial cells and perithelial cells;microvascular basal lamina severely thicken and show deposition of immunocomplex;intra epithelial cells exhibite apoptosis;degeneration of Langerhans cells.Conclusion Cell mediated immune reaction predominating in oral lichen planus has been confirmed.
出处
《现代口腔医学杂志》
CAS
CSCD
1999年第3期179-181,共3页
Journal of Modern Stomatology
关键词
口腔扁平苔藓
基底膜
免疫细胞学
电镜
Oral lichen planus\ \ Basement membrane\ \ Langerhands cell\ \ Iymphocyte Mast cell