摘要
目的探讨影响原发性食管鳞癌生存时间的因素,为预测预后提供依据。方法对2000年01月至2008年12月在江苏大学附属宜兴市人民医院进行食管癌根治性切除手术患者定期随访。采用Kaplan-Meier生存率分析和Cox比例风险模型进行单因素和多因素分析。结果患者术后1、2年与5年生存率分别为63%、51%和36%。单因素分析显示TNM分期、肿瘤浸润深度、淋巴结转移、肿瘤部位及肿瘤分化程度与术后患者的生存率相关(P<0.05);Cox分析显示,淋巴结转移是影响食管癌预后的独立因素(P<0.05)。结论多种因素影响食管鳞癌患者预后,淋巴结转移可作为食管鳞癌患者预后判断的独立因素。
Objective To explore the factors related to the prognQsis and survival duration of esophageal squamous cell carcinoma after operation. Methods 341 esophageal squamous cell carcinoma cases undergoing operation in our hospital from 2000 to 2008 were selected and related clinical data were analyzed. Kaplan-Meier analysis and Cox regression analysis was used for univariate analysis and multivariable analysis, respectively. Results The survival rate for one year was about 63 %, 51 % for two years and 36% for five years. Univariate analysis showed that TNM classification, tumor location, differentiation, invasion depth,lymph node metastasis significantly correlated with survival rates （P〈0.05）. Multivariable analysis showed that lymph node metastasis was an independent prognostic factor of esophageal squamous cell carcinoma （P〈0.05）. Conclusion Many factors are related to the prognosis and survival duration of esophageal squamous cell carcinoma after operation. Lymph node metastasis is an independent prognostic factor affecting esophageal squamous cell carcinoma.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第10期942-943,共2页
Chongqing medicine
基金
无锡市卫生局指令性基金项目(XM0903)
关键词
食管癌
预后
COX多因素分析
esophageal neoplasms
prognosis
Cox regression analysis
