摘要
一直以来,传统治疗大多无法达到黏膜愈合的目标,生物制剂的应用改变了这一观念。黏膜愈合与克罗恩病的临床复发率以及手术率的减少存在一定的关系。黏膜愈合已逐渐成为克罗恩病药物治疗的临床研究以及日常临床实践的客观指标。早期积极的药物治疗可取得更好的临床疗效和更高的黏膜愈合率这一事实正逐渐得到认同。促进并维持黏膜愈合可能有助于改变克罗恩病的自然病程。
Traditional treatment of Crohn＇s disease mostly could not achieve the goal of mucosal healing, however, the emergence and use of biological agents have changed the concept. Correlation exists between mucosal healing and the clinical recurrence rate, as well as reduction of operation rate of Crohn＇s disease. Mucosal healing is now considered as an important end point in clinical trial and is also used in clinical practice in treatment of Crohn＇s disease. Early and intensive medical treatment could achieve higher clinical efficacy and mucosal healing rate and has gradually reached a consensus. Promoting and maintaining mucosal healing might be helpful for changing the natural course of Crohn＇s disease.
出处
《胃肠病学》
2011年第2期65-67,共3页
Chinese Journal of Gastroenterology
关键词
炎症性肠病
CROHN病
治疗
黏膜愈合
Inflammatory Bowel Disease
Crohn Disease
Therapy
Mucosal Healing
