摘要
目的探讨中央静脉导管胸腔闭式引流后注入白介素-2联合顺铂治疗恶性胸腔积液的疗效。方法 48例恶性胸腔积液患者随机分为2组,均经皮胸腔穿刺,置入中心静脉导管,联合治疗组(A组)25例,胸腔内注200万单位白介素-2和40 mg顺铂;单用顺铂组(B组)23例,胸腔内注入40 mg顺铂。A、B组均接受3次化疗,每次间隔1周。观察2组疗效和不良反应。结果所有患者均获得满意引流效果;A和B组治疗总有效率分别为84.0%和60.9%,差异有统计学意义(P<0.05)。A组总不良反应发生率高于B组,但差异无统计学意义(P>0.05)。结论中心静脉置管行胸腔闭式引流术具有创伤小、活动不受限以及引流效果满意等特点。白介素-2不良反应轻,耐受性好,是治疗恶性胸腔积液较好的选择。
Objective To compare the efficacy of central venous catheter for drainage and administration of interleukin-2（IL-2）and/or cisplatin in the treatment of malignant pleural effusions.Methods Forty-eight patients with malignant pleural effusion were randomly divided into two groups.After percutaneous puncture,all the patients were embedded with a central venous catheter.Combinated therapy group（group A）was 25 cases given 200-million unit IL-2 plus 40mg cisplatin;while cisplatin group（group B） was 23 cases with cisplatin 40mg.The procedures of two groups were performed at an interval of a week for three times.The response and toxicity in the two groups were observed.Results The effectiveness of catheter for drainage in both groups was satisfactory.The response rate in A and B group were 84.0%,and 60.9% respectively,and has significant difference between the two groups（P0.05）.There was no marked difference in the incidence of side effects between two groups（P0.05）.Conclusion The closed drainage of pleural cavity with central venous catheter was with minor trauma,convenient to patients′activity and has satisfactory drainage effect.Injection with IL-2 is effective for patients with malignant pleural effusion.Its adverse effects are mild,and it is well tolerable,which warrants its widespread use in clinical practices.
出处
《实用癌症杂志》
2011年第2期181-183,共3页
The Practical Journal of Cancer
关键词
中心静脉导管
胸腔积液
白介素-2
顺铂
Central venous catheter
Pleural effusions
Interleukin-2
Cisplatin
