摘要
观察食管上皮癌变过程中TSGF（恶性肿瘤特异性生长因子）的变化：验证TSGF对早期食管癌的检测能力。方法：双盲测定食管上皮癌变不同阶段人群TSGF水平；实验数据使用SAS软件拟合（GLM）过程，用最小显著差法进行分析。结果：食管上皮病变组（食管上皮重度增生、原位癌及中、晚期癌）的TSGF水平均高于正常组，（P＜0．05）。在癌变过程中，TSGF水平逐渐增高，至癌前病变达到最高值：当癌前病变发生癌变时，TSGF水平又逐渐减少。重度增生和原位癌与中、晚期癌之间亦存在显著性差异（P＜0．05）。TSGF对于食管癌的灵敏度为90．4％，对于早期食管癌的灵敏度为95．2％，对于癌前病变的灵敏度为100％；TSGF的特异度为95．0％。结论：TSGF对于检测食管癌高危人群及早期癌是一种较为灵敏的方法，值得在高发区推广应用。
The authors measured double-blindly the level of TSGF in groups of persons at different stagesof carcinogenesis of esophageal epithelium. Lab results were processed with SAS packages andwere fitted to the general lineal mode (GLM) by the least significant difference. Results indicated thatTSGF levels rise gradually by the order of normal persons, persent esophagus cancer patients,cancer in situ patients, dysplasia patients. all of the latter three groups were significantly (P<0.05)higher than the normal persons; and the three groups varied significantly (P<0.05) among themselves.If 64u/mL was chosen to be the judgment point, then TSGF had a sensitivity rate of 90.4% (47/52)for esophagus cancer patients, a sensitivity rate of 95.2% (40/42) for early esophagus cancer patients and a sensitivity rate of 100% (16/16) for precancerous patients. The specificity rate of TSGFwas 95.0%. We consider TSGF to be a sensitive, accurate and reliable maker for the diagosis andearly detection of abnormal cases in high incidence areas.
出处
《基础医学与临床》
CSCD
1999年第4期59-61,66,共4页
Basic and Clinical Medicine
关键词
食管癌
灵敏度
上皮癌变
TSGF
TSGF Early esophagus cancer Sensitivity rate Specificity rate
