摘要
本文检测25例单纯性肾病、5例肾炎性肾病患儿外周血 T 淋巴细胞亚群,结果提示肾病两组 OKT_3、OKT_4均低于对照组,其中单纯性肾病组更为明显,其 OKT_4/T_8也低于对照组。说明小儿肾病特别是单纯性肾病的发病机制与 T 细胞功能紊乱有关。由于 OKT_4降低,OKT_8相对增强,一方面可产生各种淋巴因子损伤肾小球基底膜多阴离子诱发大量蛋白尿,另一方面使 B淋巴细胞分化成熟障碍致抗体产生不足,临床上易反复发生各种感染。
The T Lymphocytic subsets of 25 cases of Minimal Change Nephrotic Syndrome(MCNS)and 5 cases of Non-MCNS were detected,and the E rose of all cases wasexamined too.The result indicated that OKT_3 and OKT_4 were lesser in the two groups than inthe control group,especially in patients with MCNS.OKT_4/OKT_8 in MCNS waslesser than in the control group.It was suggested that the pathogenesis of pediatric NS,especially the MCNS might be disturbances of T cell subset function.OKT_4 decreasedand OKT_8 increased relatively,lymphokines were over produced.The basement memb-rance of glomerular capillaries was injured by the lymphokine,leading to profoundproteinuria.The Th(OKT_4)decreased that might cause B cell anacmesis and normalimmunoglobulin dyspoiesis,causing the patients susceptible to various infections.
出处
《天津医药》
CAS
1990年第7期413-415,共3页
Tianjin Medical Journal
