摘要
目的探讨新生血管性青光眼（Neovascularglaucoma，NVG）发病的危险因素和原发因素。方法选择2006年1月至2009年12月确诊为新生血管性青光眼的159例（178只眼）门诊或住院患者为病例组，以同期就诊，年龄相差3岁以内，相同性别为匹配条件159例非青光眼患者为对照组，对照组人群所患疾病与青光眼无相关性。首先分析病例组NVG发生的直接病因，进一步通过采集每位患者的年龄、性别、职业、吸烟史、饮酒史、心理应激状况、睡眠情况、糖尿病史、高血压病史、心血管病史、眼部手术史、眼部外伤史、近视史、远视、家族史、眼压、血压、血红蛋白、血沉、血糖、血胆固醇、血甘油三酯数据，分别运用单因素和多因素方法分析以上因素与NVG发生的关系。结果159例NVG患者直接病因分析发现视网膜静脉阻塞61例61只眼（38．4％），糖尿病视网膜病变54例（34．0％），66只眼（42．5％）。单因素分析提示吸烟史、糖尿病史、高血压病史、眼部手术史、眼部外伤史、眼压、血压、血糖、血甘油三酯9种因素在两组间的比较差异具有统计学意义（P〈0．05）．0进一步将以上因素引进行回归分析见，糖尿病史、高血压史、眼部外伤史、眼压、血糖、血甘油三酯被引入回归方程，6种因素均为NVG发生的危险因素（P〈0．10）。结论视网膜静脉阻塞和糖尿病视网膜病变是NVG发生最主要的病因；糖尿病史、高血压史、眼部外伤史、眼压、血糖、血甘油三酯为NVG发生的危险因素。
Objective To investigate the risk factors and primary factors of neovascular glaucoma. Methods A total of 159 （178 eyes） of patients who admitted in our hospital in January 2006 - December 2009 because of neovascular glaucoma were selected as case group, 159 matched patients without glaucoma were as control group. Direct causes of NVG were analyzed in case group. Further, the information of age, sex, occupation, smoking history, drinking history, psychological stress, sleep, diabetes mellitus, hypertension,cardiovascular disease, eye surgery, eye trauma history, history of myopia, hyperopia, family history, intraocular.pressure, blood pressure, hemoglobin, ESR, blood glucose, blood cholesterol and triglyceride were collected. Univariate and multivariate methods of analysis were used to analyze the relationship between these factors and the occurrence of NVG. Results Of all the direct causes of NVG, retinal vein occlusion was fotmd in 61 cases and 61 eyes （38.4%）, diabetic retinopathy in 54 cases （34.0%） and 66 eyes （42.5%）, other lesions in 44 cases （27.7%） and 51 eyes （28.7%）. Univariate analysis indicated that the factors of smoking history, diabetes mellitus, hypertension, eye surgery, history of ocular trauma, intraocular pressure, blood pressure, blood sugar, blood triglyceride had statistically significant difference between the two groups （P 〈0.05）. The factors of diabetes mellitus, hypertension, history of ocular trauma, intraocular pressure, blood sugar, blood triglyceride were introduced in regression equation. All of them were risk factors to NVG （P 〈0.10）. Conclusions Retinal vein occlusion and diabetic retinopathy are the main cause of NVG. Diabetes mellitus, hypertension, history of ocular trauma, intraocular pressure, blood sugar, blood triglyceride are NVG occurred risk factors.
出处
《中国实用眼科杂志》
CSCD
北大核心
2011年第3期228-230,共3页
Chinese Journal of Practical Ophthalmology
