摘要
目的探讨动态血糖监测系统(CGMS)和胰岛素泵持续皮下注射治疗(CSII)在重症监护病房(ICU)2型糖尿病(T2DM)患者的应用效果。方法将120例T2DM患者随机均分为三组:A组采用CGMS与CSII结合治疗模式(40例),B组采用单纯CSII治疗(40例),C组采用胰岛素多次注射治疗(40例)。后两组采用指端毛细血糖监测法。治疗7d后比较三组血糖控制情况、血糖达标率及血糖漂移情况。结果治疗7d后,A组和B组患者的全日血糖、平均血糖(MBG)、平均血糖波动幅度(MAGF)均较治疗前明显下降,且明显优于C组(P<0.05),低血糖发生次数亦较C组明显减少(P<0.05)。其中,A组MBG、MAGE、低血糖次数均显著低于B组(P<0.05)。结论 CGMS能监测血糖连续的变化曲线,及时发现高血糖和低血糖,与胰岛素泵联合治疗更有利于ICU糖尿病患者血糖的控制,降低低血糖的发生率。
Objective To investigate the therapeutic outcomes of continuous glucose monitoring system（CGMS） and continuous subcutaneous insulin infusion pump system（CSII） in type 2 diabetes mellitus（T2DM） patients with critical condition in intensive care unit（ICU）.Methods A total of 120 T2DM patients in ICU was randomly divided into three groups with 40 cases each.CGMS combined with CSII was used in group A,CSII alone in group B and repeated injection of insulin therapy in group C.The capillary blood glucose of finger tip was monitored in groups of B and C.The changes of fasting blood glucose（FBG）, mean amplitude of glycemic excursions（MAGE） and the number of hypoglycemia events were recorded and compared among three groups after for treatment 7 days.Results After pump therapy for 7 days, the whole day glucose, MBG and MAGE were all significantly lower in groups of A and B than those before treatment（P0.05）,which were lower in group A than those in group B（P0.05）.The mean blood glucose（MBG）, mean amplitude of glucose fluctuation（MAGF） and hypoglycemia events of group A were obviously less than those in group B（P0.05）. Conclusion CGMS can depict a continuous blood glucose curve,discover hyperglycemia or hypoglycemia events. CGMS combined with CSII is more beneficial to the glucose control in the critical T2DM patients in ICU.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第3期287-289,共3页
Jiangsu Medical Journal
基金
江苏省自然科学基金资助项目(BK2007253)
关键词
2型糖尿病
动态血糖监测系统
胰岛素泵
Type 2 diabetes mellitus
Continuous glucose monitoring system
Insulin infusion pump
