摘要
目的:检测皮肤鳞状细胞癌组织中E-钙黏素和α-SMA的表达。方法:用免疫组化法检测30例皮肤鳞状细胞癌组织中E-钙黏素和α-SMA蛋白的表达。结果:与癌旁及正常皮肤组织相比,E-钙黏素在皮肤鳞状细胞癌中表达减弱或缺失(P<0.05),中低分化与高分化癌组织组间比较差异有显著性(P<0.05);皮肤鳞状细胞癌癌巢周边组织中α-SMA阳性表达,中低分化与高分化癌组织组间比较差异也有显著性(P<0.05)。结论:皮肤鳞状细胞癌发生上皮-间质转化,肿瘤相关成纤维细胞可能参与了其转化和侵袭过程。
Objective： To detect the expression of E - eadherin and α - SMA in cutaneous squamous cell carcinoma （CSCC）. Methods： The expression of E- cadherin and α- SMA in 30 patients with cutaneous squamous cell carcinoma was detected with immunohistochemical method. Results： Compared with pe.ricancerous and normal tissues, the expression rate of E - cadherin in CSCC was lower or lost （ P 〈 0.05 ） and the expression was also differed between higher and lower differentiation of the cancer （ P 〈 0.05 ）. The expression of α - SMA was positive in peri- cancerous tissue and differed between higher and lower differentiations of the cancer （ P 〈 0.05）. Conclusion： In CSCC, there may be epithelial- mesenchymal transition in which cancerassociated fibroblasts may be involved.
出处
《中国麻风皮肤病杂志》
2011年第2期87-89,共3页
China Journal of Leprosy and Skin Diseases
