摘要
目的:探讨重性抑郁症患者不同维度生存质量与其症状变化的相关性。方法:采用前瞻性研究设计,用健康状况问卷(SF-36)对103例重性抑郁症患者进行基线期和治疗6周末的评估,在基线、治疗2周末和6周末还同时评估汉密尔顿抑郁量表(HAMD)和临床总体印象量表(CGI)。结果:治疗6周末,患者SF-36因子分均高于基线(P<0.01)。治疗2周和6周末,HAMD总分及各因子分(体质量因子除外)、CGI分均低于基线分(P<0.01)。基线期痊愈组SF-36情感职能显著低于未痊愈组[(2.08±8.20)分vs.(5.63±14.89)分],差异有统计学意义(P<0.01),其他各因子分2组差异均无统计学意义(P>0.05);治疗6周末,2组除躯体疼痛因子与基线期差异无统计学意义(P>0.05),其他各因子分均高于基线(P<0.05或P<0.01);痊愈组躯体职能、一般健康状况、精力、社会功能及精神健康分高于未痊愈组(P<0.05或P<0.01)。基线SF-36总分与HAMD总分及认知障碍因子、CGI总分均呈显著负相关(P<0.05或P<0.01);治疗2周末,一般健康与认知障碍减分率、精力和健康变化与睡眠障碍减分率呈正相关(P<0.05);治疗6周末,健康变化分别与基线HAMD和睡眠障碍、一般健康状况和情感职能分别与基线焦虑/躯体化因子分呈负相关(P<0.05或P<0.01)。结论:重性抑郁症患者接受6周抗抑郁剂治疗后其生存质量可能得到普遍改善,不同维度生存质量的改善可能与不同症状的基线水平和早期改善程度相关。认知障碍的早期改善可能有利于改善治疗6周后的一般健康状况,睡眠障碍的改善则有助于患者恢复精力和改善对自身健康状况总体变化的评价。
Objective To investigate the association between health related quality of life（HRQoL） and severity of depression in patients with major depressive disorder（MDD）.Methods Short Form 36 Health Survey Questionnaire（SF-36） was administered to 103 MDD patients at the baseline and 6-week follow-up.Hamilton Depression Rating for Depression（HAMD） and Clinical Global Impression（CGI） were administered at the baseline,2-and 6-week follow-up,respectively.Results All SF-36 component scores in the 6-week follow-up were significantly higher than those at the baseline（P0.01）.The overall and subscale scores of HAMD except weight and CGI scores at the 2-and 6-week follow-up were significantly lower than those at the baseline（all P0.01）.The role-emotion score of the clinical remission group was significantly lower than that of the non-remission group.After a 6-week antidepressant treatment,all SF-36 component scores in both groups were significantly higher than those at the baseline,except body pain in the non-remission group.While scores of role-physical,general health,vitality,social functioning,role-emotion and mental health were significantly higher in the remission group than those in the non-remission group（P0.05 or P0.01）.A higher overall score of HAMD,scores of cognitive disturbance and CGI were significantly associated with a worse SF-36 at the baseline（P0.05 or P0.01）.After the 6-week treatment,a worse health transition was significantly associated with higher scores of HAMD and sleep disturbance at the baseline（P0.01）,a worse general health and role-emotion were strongly associated with higher score of anxiety/somatization at the baseline（both P0.05）.Score of general health was positively associated with reduction rate of cognitive disturbance at the 2-week endpoint（P0.05） and scores of vitality and reported health transition were positively associated with the reduction rate of sleep disturbance at the 2-week endpoint（both P0.05）.Conclusion The increasing severity of d
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2011年第2期143-148,共6页
Journal of Central South University ：Medical Science
关键词
重性抑郁症
生存质量
症状
相关性
前瞻性
major depressive disorder
health related quality of life
severity
correlation
prospective
