摘要
目的探讨一种安全、有效的幽门螺杆菌（Helicobacter pylori,H.pylori）感染相关消化性溃疡的治疗方案,评价含铋剂的H.pylori根除方案的疗效。方法 2009年1月~2009年12月符合H.pylori感染相关消化性溃疡诊断标准的患者66例,随机分为用枸橼酸铋雷尼替丁0.4＋克拉霉素0.25＋甲硝唑0.4治疗34例和雷贝拉唑10 mg＋克拉霉素0.25＋甲硝唑0.4治疗32例,均为2次/d×7 d,之后治疗组予以枸橼酸铋雷尼替丁0.4,2次/d,对照组雷贝拉唑10 mg,2次/d,巩固治疗35 d。系统治疗完成后6~8周复查胃镜及14C呼气试验检测H.pylori。结果治疗组痊愈20/34（58.8%）,有效9/34（26.5%）,总有效率为85.3%;对照组痊愈18/32（56.3%）,有效8/32（25.0%）,总有效率为81.3%,两组总有效率比较差异无统计学意义（P〉0.05）。结论含铋剂的根除H.pylori方案与雷贝拉唑加克拉霉素、甲硝唑2种抗生素的根除方案治疗H.pylori感染相关溃疡总有效率相近,但具有疗效显著,不良反应轻微的优点。
Objective To explore the effect of Ranitidine Bismuth Citrate in H.pylori eradication in the peptic ulcer population.Methods Sixty-six cases of gastric or duodenal ulcer patients with positive H.pylori received the treatment of Ranitidine Bismuth Citrate capsules（34 cases） or rabeprazole（32 cases）,plus the clarithromycin and metronidazole.All patients were subjected to H.pylori eradication therapy for 7 days,followed by the only treatment of Ranitidine Bismuth Citrate capsules（0.4,Bid） or rabeprazole（10 mg,Bid） for another 35 days.Patients were performed dupper endoscopy 6~8 weeks after completion of all the treatment.The rate of ulcer healing and the eradication rate of H.pylori were observed.Results The excellent patients were 20/34（58.8%） and effective patients were 9/34（26.5%）,the curerate rate of Ranitidine Bismuth Citrate capsules of the therapy goup was 85.3%;at the same time,excellent patients were 18/32（56.3%） and effective patients were 8/32（25.0%） in control group,and the curerate rate of the control group was 81.3% in control group.There was no significant difference between the two groups（P0.05）.Conclusion The 7-days therapy with Bismuth Citrate capsules is worthy of clinical application in curing the H.pylori relative peptic ulcer.
出处
《胃肠病学和肝病学杂志》
CAS
2011年第2期169-170,共2页
Chinese Journal of Gastroenterology and Hepatology
