摘要
目的观察两性霉素B与两性霉素B脂质体对恶性血液病患者侵袭性真菌感染的临床疗效及不良反应。方法回顾用两性霉素B与两性霉素B脂质体治疗恶性血液病合并侵袭性真菌感染病例。A组:(两性霉素B组20例),B组(:两性霉素B脂质体组19例)。结果临床总有效率A组为75.0%,B组84.2%,;A组不良反应畏寒、寒战、发热,低血钾血症,消化道反应,肾功能损害,肝功损害及静脉炎的发生率分别为55.0%、45.0%、20.0%、15.0%、10.0%、10.0%;B组分别为5.2%、26.3%、10.5%、5.2%、5.2%、5.2%。结论两性霉素B脂质体较两性霉素B疗效略高,两性霉素B副作用较两性霉素B脂质体大,但两性霉素B价格便宜,是治疗侵袭性真菌感染比较安全有效、经济的选择。
Objective To compare the therapeutic effect and side effects of conventional between amphotericin B and liposomal amphotericin B in thetreatment of invasive fungal infections（IFI） in immunocompromised patients. Methods We retrospectively analyzed 39 diagnosed patients with invasive fungal infections（IFI） in immunocompromised patients who treated in our hospital.20cases in A group were treated with amphotericin B while 19 cases in B group were treated with liposomal amphotericin B.Results The Clinical efficacy rate of amphotericin B was 75. 7%, while efficacy rate of liposomal amphotericin B was 84.2%.A group the side effects of conventional such as chill,hypokalemia, gastrointestinal symptoms, kidney damage ,hepatic damage were 55.0% 45.0%,20.0%,15.0%,10.0%,10.0% while B group were 5.2% 26.3% 10.5% 5.2% 5.2% 5.2%. Conclusion Liposomal amphotericin B is more effective,while there is liter side-effects but amphotericin B is more cheaper than liposomal amphotericin B. Conventional amphotericin B is effective and less expensive and safe in treatment .
出处
《当代医学》
2011年第9期102-103,共2页
Contemporary Medicine
关键词
两性霉素B
两性霉素B脂质
侵袭性真菌感染
Amphotericin B
Liposomal amphotericin B
Invasive fungal infections（IFI）
