摘要
目的探讨侧链酸的合成工艺及结构确证。方法以氰基乙酰胺为起始原料,经烷化,羟肟化,环合、酰胺水解反应合成了头孢菌素类的关键中间体2-(5-氨基-12,4,-噻二唑-3-基)-2-甲氧基亚氨基乙酸。结果四步主要反应的收率分别是73.2%,66.3%6,2.5%3,3.3%,总收率为10.1%。结论该合成工艺操作简便,收率高,是合成侧链酸的较好方法。通过元素分析、红外吸收光谱及核磁共振谱确证了侧链酸的结构。
Aim To explore the synthesis and structural identification of side chain acid.Methods The important intermediate for cephalosporin,2-（5-amino-1,2,4-thiadiazol-3-yl）-2-（methoxyimino） acetic acid was synthesized by the methods of alkylation,oximate,cyclization and hydrolyzation using cyano acetamide as raw material.Results The yields of the four steps were 73.2%,66.3%,62.5% and 33.3%,respectively.The overall yield was 10.1%.Conclusion It＇s a better process with simple procedure,good yield.The structure was identified by elemental analysis,IR and NMR.
出处
《安徽医药》
CAS
2011年第3期294-296,共3页
Anhui Medical and Pharmaceutical Journal
