摘要
剂量补偿效应是表观遗传的机制之一,它是指使X连锁基因的表达水平在两性间达到平衡的过程。不同的物种所实现剂量补偿的机制不同,人同其他哺乳动物的剂量补偿机制是雌性个体随即失活一条X染色体。但最近的研究发现,在人和小鼠的失活X染色体上有些基因仍能表达,逃避了失活。目前,许多人类疾病尤其是具有女性发病优势病症的发生与治疗可能与这些逃逸基因密切相关。针对以上内容的最新进展作了相关综述。
Dosage compensation effect is one of epigenetic mechanism,it is the process that the levels of X linked gene expression is equalized between the sexes.However,the mechanisms of dosage compensation in different species is different,it is achieved by randomly inactivating one of the two X chromosomes in the female individuality for human being and mammals.In recent years,although X chromosomes was inactivated,some genes still were expressed in human and mouse.Nowadays,it is found that the etiologies and treatments of some human diseases,especially those are high incidence to women,probably related to these genes.Hence,the latest research progresses about it were reviewed in this article.
出处
《畜牧与饲料科学》
2011年第1期26-27,31,共3页
Animal Husbandry and Feed Science
关键词
剂量补偿
X染色体失活
失活逃逸
疾病
dosage compensation
X inactivation
XCI escaping
diseases
