摘要
目的:观察前交叉韧带、半月板损伤后膝关节周围骨密度的变化,探讨其影响因素及可能的影响机制。方法:健康纯种新西兰大白兔16只随机分为前交叉韧带切断组8只,半月板切除+前交叉韧带切断组8只,分别于造模前、造模后第48、1、2周末测量膝关节周围4个目的区的骨密度,比较各目的区不同造模方法、不同时间点间骨密度的变化。结果:R3区,A组骨密度低于B组,差异有统计学意义(F=22.326,P=0.001);各时间点间骨密度差异有统计学意义(F=7.031,P=0.033);R4区,两种造模方法间骨密度差异有统计学意义(F=14.821,P=0.007),各时间点间骨密度差异有统计学意义(F=5.632,P=0.031);造模方法和测量时间无交互作用(R3区:P=0.063;R4区:P=0.055)。R1、R2区,造模方法间骨密度值差异均无统计学意义(F=2.330,P=0.057;F=1.960,P=0.081);各时间点间骨密度值差异无统计学意义(F=2.190,P=0.074,F=2.510,P=0.067)。结论:前交叉韧带切断、半月板切除术后膝关节周围发生骨密度改变可能是适应性骨重建作用的结果,关节不稳、应力改变是主要的影响因素。
Objective：To observe the change of bone mineral density（BMD）around the knee joint after anterior cruciate ligament（ACL）injury and meniscus injury,and to explore the influencing factors and the possible mechanism for the change.Methods：16 healthy New Zealand pure rabbits were randomly divided into ACL transection group（group A）and meniscectomy combined with ACL transection group（group B）,8 cases in each group.BMD of the 4 regions of interesting around the knee joint of the rabbits were measured before model building and at the 4th,8th,12th weekend after model building respectively.The change of BMD of the 4 regions of interesting were compared between different methods of model building and between different time points.Results：In the region 3,BMD of group A was lower than that of group B,and there was statistical difference between the 2 groups（F=22.326,P=0.001）;and there was statistical difference in BMD among different time points（F=7.031,P=0.033）.In the region 4,there was statistical difference in BMD between the 2 methods of model building（F=14.821,P=0.007）,and there was statistical difference in BMD among different time points（F=5.632,P=0.031）,and there was no interaction between molding method and measurement time（region 3：P=0.063;region4：P=0.055）.In the region 1 and region 2,there was no statistical difference in BMD between the different molding methods（F=2.330,P=0.057;F=1.960,P=0.081）,and there was no statistical difference in BMD among the measurement time points（F=2.190,P=0.074,F=2.510,P=0.067）.Conclusion：It is possible that BMD change around the knee joint after ACL transaction and meniscectomy is the result of adaptive bone remodeling,and joint instability and stress change may play an important role in the process.
出处
《中医正骨》
2011年第3期6-8,共3页
The Journal of Traditional Chinese Orthopedics and Traumatology
关键词
膝关节
前交叉韧带
半月板
胫骨
骨密度
动物实验
兔
Knee joint
Anterior cruciate ligament
Menisci
Tibal
Bone density
Animal experimentation
Rabbits
