摘要
目的系统评价针刺治疗脑卒中后呃逆的疗效及安全性。方法计算机检索PubMed、Cochrane图书馆、CNKI、VIP和万方数据库,查找有关针刺治疗脑卒中后呃逆的随机对照试验,检索时间截至2010年6月。按Cochrane系统评价方法对纳入研究进行质量评价和资料提取后,采用RevMan软件进行Meta分析。结果共纳入3个RCT,包括143例患者。Meta分析结果显示:针刺+药物组治疗脑卒中后呃逆的疗效优于药物组,其差异有统计学意义[OR=9.05,95%CI(3.17,25.82),P<0.000 01],3个纳入研究均未报道不良反应。结论本系统评价结果提示,针刺有短期改善脑卒中后呃逆的趋势,且无不良反应。由于3个纳入研究均为低质量研究且例数有限,观察随访期又小于3个月,因此,目前尚不能对其远期疗效得出肯定结论,现有证据不足以推荐针刺作为脑卒中后呃逆的常规治疗手段。开展更多高质量、大样本、多中心的随机对照试验非常必要。
Objective To assess the efficacy and safety of acupuncture for patients with hiccups after stroke.Methods The randomized controlled trials（RCTs） of acupuncture for patients with hiccups after stroke were collected by searching PubMed,The Cochrane Library,CNKI,VIP,and WangFang databases.The quality of the included studies was evaluated and the data were retrieved according to the methods recommended by the Cochrane Collaboration.Meta-analyses were conducted by using RevMan software.Results Three trials involving 143 patients were included.All of them were open-label controlled without observing the effective rate and mortality rate（or dependence rate） at the end of follow-up visit lasting for at least three months.The result of meta-analyses showed that the group of acupuncture plus drug was more effective for hiccup after stroke than the drug group at the end of the treatment,and the difference was significant（OR=9.05,95%CI 3.17 to 25.82,P0.000 01）.The three studies did not report any adverse reactions.Conclusion Although the acupuncture has the short-term improvement trend without adverse events for hiccups after stroke,the confirmed conclusion of long-term effectiveness has not yet been reached because both the methodological quality and the quantity of all included studies are poor,and especially the long-term outcome measures are insufficient.There is no enough evidence to recommend acupuncture as a routine treatment for hiccups after stroke.So more high-quality multi-center RCTs in large scale are required.
出处
《中国循证医学杂志》
CSCD
2011年第3期325-328,共4页
Chinese Journal of Evidence-based Medicine
关键词
针刺
脑卒中
呃逆
系统评价
META分析
随机对照试验
Acupuncture
Stroke
Hiccups
Systematic review
Meta-analysis
Randomized controlled trial
