摘要
目的:研究血管紧张素转化酶抑制剂治疗充血性心力衰竭的临床效果。方法:将70例充血性心力衰竭的患者随机分为治疗组和对照组,对照组(n=27)给予常规治疗(强心、利尿、扩血管),治疗组(n=43)在常规治疗的基础上加用血管紧张素转化酶抑制剂,两组服药前后检查心率、6分钟步行测验、血压、LVEF、LVDD、心功能并进行比较。随访9月。结果:ACEI治疗组CHF后症状改善,心率减慢,血压下降、6分钟步行距离增加,治疗组临床指标改善明显,心功能改善总有效率达88.3%,对照组总有效率达74%,两个比较有统计学意义。结论:ACEI治疗CHF可明显改善心功能,提高生存率及生活质量,延缓心室重塑的发展,从而降低心力衰竭的死亡率,安全有效,值得推广。
Objective： To study the clinical effect of angiotensin--converting enzyme inhibitor（ACEI）tOtreat congestive heart failure（CHF）. Methods：Chose 70 cases the congestive heart failure were randomly dividedinto treatment and control groups, treatment groups（n= 43）used ACEI on routing treatment base. Dose fromlow to＇ target dose＇ step to step. In the control groups（n= 27） were given only routine treatment（Cardiotoni, Diureticand Vasodioctive）. Test heart rate,Blood pressure, the distance fur 6 minutes walking test, LVDD, LVEFand heart function grade. Then compared the changes before and after treatment and assessed the clinical effects. Patients were followed up for 2years. Results： After ACEI treated CHF, the heart rate decreased, blood pressurelower, 6 -minute walking distance increase, the heart function improved obviously,the valid rate reached 88.3%,the control groups only 74 % o the statistieaiogy signiticanfly compared on two groups（P〈0.01）. Conclusion：ACEI treat CHF improves the heart function, survival rate and living quality. The cardic remodeling developing wereprevent and postpone. So dead rate and admission reduced.
出处
《心血管病防治知识（学术版）》
2011年第2期1-2,7,共3页
Prevention and Treatment of Cardiovascular Disease
关键词
血管紧张素转换酶抑制剂
心力衰竭
治疗
安全性
Angiotensin - converting enzyme inhibitor （AcEI）
Congestive heart failure （CHF）
Treatment
safety
