摘要
二甲双胍是常见的降糖药物，大量研究表明其可能有抗肿瘤作用，机制包括：（1）激活细胞内的AMP活化蛋白激酶（AMPK）信号通路。（2）抗炎作用。慢性炎性反应与肿瘤的发生可能有关，二甲双胍能更有效减少炎性因子及C反应蛋白的水平。（3）提高T细胞的记忆，增强免疫系统对癌细胞和病毒感染的反应能力。（4）调控相关细胞凋亡因子。（5）导致肿瘤中细胞周期蛋白D1蛋白水平的大幅降低。
Metformin is a common antidiabetic drug. Most researches indicated that metformin may have the anti-tumor function, its mechanism includes： （ 1 ） Activation of AMP-activated protein kinase （AMPK） signal pathway. （2）Anti-inflammation function. Chronic inflammation may be related with cancer, and metformin can reduce the inflammatory factor and the C- reactive protein density effectively. （3）Enhan- cing the memory of T cell, and the function of immune system to the cancer cell and viral infection. （4） Regu- lating the related apoptosis factors. （5）Leading to the significant reduction of ceil cycle protein D1 level of tumor.
出处
《国际内分泌代谢杂志》
2011年第2期138-140,共3页
International Journal of Endocrinology and Metabolism
