摘要
环境内分泌干扰物是普遍存在于环境中的一类化学物质，能够造成机体内分泌系统功能紊乱。环境内分泌干扰物易被机体吸收而不易排出，相互之间具有协同作用，且具有遗传性及传代性，因此能严重影响人类的健康。环境内分泌干扰物可以导致下丘脑一垂体一性腺轴形态和功能的改变，影响其调节功能；干扰雌激素的代谢及转运，提高体内雌激素水平；激活雌激素受体，增强其敏感性，从而导致青春期发育提前。
Environmental endocrine disruptors are pollutants of many chemical classes, which are ubiquitous and persistent in the environment and can exert adverse effects on the endocrine system. Environ- mental endocrine disruptors are easily absorbed by the body, but not excreted. They are synergistic and hereditary. Therefore, environmental endocrine disruptors will severely destroy public health. Environmental endocrine disruptors, bringing about changes in morphology and function of the hypothalamus-pituitary-gonadal axis, interfering with the metabolism and transportation of estrogen, improve estrogen levels. They can activate estrogen receptor and enhance its sensitivity. By these means, environmental endocrine disruptors lead to early puberty development.
出处
《国际内分泌代谢杂志》
2011年第2期107-109,115,共4页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（30371820）
关键词
内分泌干扰物
青春期
早熟
Endocrine disruptors
Puberty
Precocious
