摘要
以3,4-二甲氧基苯甲醛为原料,经过缩合、还原、环合得到5,6-二甲氧基-1-茚酮,总收率为74.7%。以4-哌啶甲酸乙酯为原料,经苄基化、还原、氯化,得到1-苄基-4-氯甲基哌啶,总收率52.5%。经1H NMR、FTIR、MS分析确认为目标产物。
5,6-Dimethoxy-1-indanone was synthesized by using 3,4-dimethoxy benzaldehyde as raw materials through condensation,reduction and cyclization.1-Benzyl-4-formyl-piperidine was synthesized by using 4-ethyl piperidine through benzylation,reduction and chlorination.The overall yield for two intermediates was 74.7% and 52.5%,respectively.The structure of goal product was confirmed by 1H NMR,FTIR and MS spectroscopy.
出处
《应用化工》
CAS
CSCD
2011年第2期274-276,280,共4页
Applied Chemical Industry
