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托吡酯对癫痫患儿血镁变化及骨代谢指标的影响 被引量:2

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摘要 目的探讨抗癫痫药托吡酯(TPM)对癫痫患儿血镁和骨代谢的影响。方法对60例癫痫患儿予口服TPM治疗,分别于治疗前和治疗后3,6个月上午空腹采静脉血测血钙(ca).磷(P)、镁(mg)、骨源性碱性磷酸酶(BAP)及测定骨密度(BMD)。对照组为40名正常健康体检儿童,同期检测上述指标。结果托吡酯治疗前血清Ca、P、Mg,BAP、BMD与对照组比较差异均无显著性(P均〉0.05),治疗后6个月实验组惠儿的血钙及BMD较治疗前明显降低,差异有显著性(P〈0.05),余指标之间差异无显著性(P均〉0.05)。结论服用托吡酯(TPM)对2—12岁癫痫患儿骨代谢有影响,对血镁无影响。
出处 《中国卫生产业》 2011年第1期59-61,共3页 China Health Industry
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