摘要
目的探讨血浆致动脉硬化指数（AIP）与2型糖尿病足背动脉粥样硬化病变程度的关系。方法选取我院2型糖尿病患者127例，其中足背动脉粥样硬化66例，非动脉粥样硬化61例，选择我院同期体检健康者33名为健康对照组，应用彩色多普勒超声测定其足背动脉内膜中膜厚度（IMT），并测定其血甘油三酯、高密度脂蛋白胆固醇等代谢指标，计算AIP。用单因素方差分析比较3组各指标差异，并对各指标进行Pearson相关性分析。应用ROC曲线确定AIP对2型糖尿病足背动脉粥样硬化的最佳诊断工作点（OOP）。结果动脉粥样硬化组、非动脉粥样硬化组和健康对照组AIP分别为0．229±0．132、0．112±0．074、-0．045±0．033，IMT分别为（0．71±0．24）、（0．49±0．09）、（0．34±0．15）mm，组间差异均有统计学意义（F值分别为88．015、54．892，P值均为0．001）。经校正可能的影响因素，AIP仍与IMT呈正相关（r=0．315，P：0．001）。AIP的最佳诊断工作点为0．1671，曲线下面积为0．783。结论AIP与2型糖尿病足背动脉粥样硬化相关性良好，其OOP具有较好的诊断参考价值。
Objective To investigate the relationship between Atherogenic Index of Plasma（AIP） and the dorsalis pedis artery atherosclerosis in type 2 diabetes. Methods One hundred and twenty-seven patients with type 2 diabetes and 33 healthy individuals were included in the study. The diabetic patients were derided into 2 groups, with （ n = 66 ） or without （ n = 61 ） atherosclerosis. The intima media thickness （IMT） of dorsalis pedis artery were measured by B-mode Doppler uhrasonograpby. The triglyceride （TG）, high density lipoprotein- cholesterol（HDL-C） and other glncolipid metabolic indices were measured in all patients. The AIP was defined as the log value of TG/HDL-C ratio. The one-way ANOVA test was performed to determine the differences among three groups. The relationships between IMT and the other indicators were assessed using Pearson bivariate correlations analysis. The optimal operating point of AIP to diagnose the dorsalis pedis artery atherosclerosis in type 2 diabetes was obtained by drawing ROC curve. Results The AIP value in atherosclerosis diabetic patients ,no-atheroscleresis diabetic patients and healthy subjects were 0. 229 ± 0. 132,0. 112 ± 0. 074 and - 0. 045 ± 0. 033 respectively. The IMT value were （0. 71 ±0. 24 ）mm, （0.49 ± 0.09 ）mm and （0. 34 ± 0. 15 ）mm respectively. Both indices shown statistical differences among the three groups （Ps = 0. 001 respectively）. After adjusting for potential influence factors, AIP showed positive correlation with IMT（ r = 0. 315 ,P = 0. 001 ）. The OOP of AIP was 0. 1671 ,the area under the curve was 0. 783. Conclusion AIP was well related to the dorsalis pedis artery atherosclerosis in type 2 diabetes, and the OOP of AIP had good diagnostic reference value in these patients.
出处
《中国综合临床》
2011年第3期273-276,共4页
Clinical Medicine of China
