摘要
目的探讨慢性丙型肝炎患者(CHC)伴发代谢综合征(MS)的相关危险因素。方法收集2007年～2008年该院门诊和住院收治的CHC患者146例,根据患者是否伴有MS分为两组:MS组(21例)和非MS组(125例)。对两组患者年龄、性别、BMI、血压、血脂、FBG、FINS、HOMA-IR、肝功能、脂肪肝发生率、病毒载量及基因分型等因素进行比较,用logistic回归分析危险因素。结果 MS组患者的TC、TG、LDL-c、HDL-c、FBG、FINS,HOMA-IR和病毒载量的水平及脂肪肝发生率均明显高于非MS组(P<0.05或P<0.01)。Logistic逐步回归分析显示,LDL-c、FINS、HOMA-IR、病毒载量及脂肪肝是慢性丙型肝炎合并代谢综合征的独立危险因素。结论 LDL-c、FINS、HOMA-IR、病毒载量及肝脏脂肪变性对CHC患者的MS发生、发展有着重要的意义,是其独立危险因素。
【Objective】 To investigate the risk factors of metabolic syndrome in chronic hepatitis C.【Methods】 146 patients from 2007 to 2008 and with chronic hepatitis C were studied.The patients were divided into two groups depending on the diagnose of metabolic syndrome,group with MS（21 patients） and group without MS（125 patients）.The groups were compared in terms of age,gender,BMI,blood pressur,TC,TG,LDL-c,HDL-c,FBG,FINS,HOMA-IR,HCV RNA,HBV genotype and the rate of hepatosteatosis.The risk factors were analyzed by multivariate Logistic regression analysis.【Results】 In the group of chronic hepatitis C with MS,the TC,TG,LDL-c,HDL-c,FBG,FINS,HOMA-IR,HCV RNA and the rate of hepatosteatosis were significantly higher than those in the group without MS（P 0.05 or P 0.01）.The logistic regression show that the LDL-c,FINS,HOMA-IR,HCV RNA and hepatosteatosis are all statistically significant.【Conclusion】 LDL-c,FINS,HOMA-IR,HCV RNA and hepatosteatosis are the risk factors of metabolic syndrome in chronic hepatitis C.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第2期306-308,共3页
China Journal of Modern Medicine
