摘要
目的建立一步法制备2-氨基-6-氯嘌呤(1)合成工艺。方法以鸟嘌呤、三氯氧磷等为原料,在四乙基氯化铵作用下,在乙腈中经一步反应制得2-氨基-6-氯嘌呤。结果目标化合物经红外光谱和质谱确证化学结构,产率达到72.1%,纯度达98%。结论为2-氨基-6-氯嘌呤的工业化生产提供了一条较为合理的工艺路线。
Objective To find a one-step synthetic method of 2-amino-6-chloropurine. Methods 2-amino- 6-chloropurine was synthesized using guanine and phosphorus oxychloride as starting materials under the effect of tetraethylamine chloride in acetonitrile. Results The chemical structure of the target compound was confirmed by IR, MS and 13C NMR etc. The yield of title compound was（72.1% and its HPLC purity was not less than 98%.Conclusion This article can provide a more reasonable route for the production process of 2-amino-6-chloropurine.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2011年第3期205-206,共2页
Chinese Journal of Antibiotics
