摘要
急性呼吸道感染(ARTIs)是人类健康的主要威胁,据统计每年有400万儿童死于各类呼吸道感染导致的肺炎。90%以上的ARTIs是由病毒引起,但仍有大约30%的ARTIs病原不能确定。WU多瘤病毒于2007年由美国学者Gay-nor等通过高通量序列测定从肺炎患者的呼吸道标本中发现,但是否为呼吸道致病原还存在争议。目前的研究热点多集中在WU多瘤病毒的致病性和流行病学特点方面。该病毒属于多瘤病毒科多瘤病毒属,生物学性状与该属病毒相似。该病毒多在儿童标本中检出,其季节分布稍有差异。WU多瘤病毒与其他呼吸道病毒混合感染常见,故是否为一种独立的致病原还需进一步研究。目前的研究方法多采用PCR和荧光定量PCR扩增技术。
Acute respiratory tract illness（ARTI） is the most common disease experienced by people of all ages,and especially young children,worldwide.About 4000,000 children die of pneumonia caused by ARTI.About 90% of pathogens causing respiratory infection are viruses,but about 30% of ARTI pathogens remain unidentified.WU Polyomavirus（WUPyV） was first identified by Gaynor using high through-put sequencing of respiratory samples from patients with pneumonia.Whether WUPyV is a pathogenic organism remains unknown.Current research has focused more on the pathogenicity and epidemiology of WUPyV.WUPyV belongs to Polyomaviruses of the family Polyomaviridae.Its biological properties are similar to those of other Polyomaviruses.WUPyV is frequently detected in young children.The seasonal distribution of WUPyV varies in different studies.WUPyV is often part of a mixed infection with other respiratory viruses.Whether WUPyV is a sole pathogen must be studied further.Current studies have often used PCR and real-time PCR to detect WUPyV.
出处
《中国病原生物学杂志》
CSCD
2011年第2期147-149,共3页
Journal of Pathogen Biology
基金
天津市科技支撑重大项目(No.07SYSYSF05100)
