摘要
特发性肺纤维化（idiopathic pulmonary fibrosis，IPF）是一种发病原因不明预后不佳的间质性肺疾病。目前一些研究发现慢性隐匿性误吸是IPF发病原因之一．尽管两者之间的具体联系还没得到病理生理学证实。流行病学研究发现胃食管反流病作为一种慢性误吸的典型疾病，是IPF发病的危险因素。本文旨在临床和生物学角度阐述两者的联系，增强对IPF发病原因的理解，进一步提高IPF的治疗水平。
Idiopathic pulmonary fibrosis （IPF） is a diffuse fibrotic lung disease of unknown etiology with no effective treatment. Emerging data support a role for chronic aspiration in the natural history of IPF. However, the precise relationship between chronic aspiration and IPF remains unknown. Gastroesophageal reflux, a presumed risk factor for aspiration, has been strongly associated with IPF with an estimated prevalence of up to 90%. This review aims to describe the relationship between chronic aspiration and IPF by laying out the clinical and biologic rationale for this relationship and exploring the scientific evidence available.
出处
《国际呼吸杂志》
2011年第5期393-397,共5页
International Journal of Respiration
关键词
病因学
胃食管反流
特发性肺纤维化
慢性隐匿性误吸
Etiology
Gastroesophageal reflux
Idiopathic pulmonary fibrosis
Respiratory aspiration
