摘要
目的探讨医院感染多药耐药铜绿假单胞菌的耐药特性,为临床医师合理用药提供试验依据。方法严格按照《全国临床检验操作规程》进行细菌培养;采用法国生物梅里埃公司VITEK-32全自动微生物分析仪鉴定菌株;采用K-B法进行药敏试验。结果 287株多药耐药铜绿假单胞菌中检出24.4%的泛耐药株;对亚胺培南、美罗培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦已产生了24.4%-25.4%耐药率,对其他常用抗菌药物的耐药率均〉40.0%,且耐药率呈逐年升高趋势。结论医院务必对多药耐药铜绿假单胞菌进行严密的监测,加强抗菌药物用药管理,遏制多药耐药细菌导致的医院感染暴发流行。
OBJECTIVE To investigate the antibiotics resistance of multidrug-resistant Pseudomonas aeruginosa（MRPA） causing nosocomial infection in Jingzhou and provide the experimental evidence for clinically reasonable use of the antibiotics.METHODS Referring to National Guide to Clinical Laboratory Procedures,the strains were cultured.The Mérieux VITEK32 was used to identify the strains.The susceptibility testing was performed by K-B methods.RESULTS A total of 24.4% pan-resistant strains were found in 287 isolates of MRPA.The resistance rates to imipenem,meropenem,piperacillin/tazobactam and cefoperazone/sulbactam arrived at 24.4%-25.4%,and which to other antibiotics were all above 40.0% and were increasing annually.CONCLUSION Rigorous monitoring of MRPA should be performed,the antibiotic management should be strengthened to prevent the outbreak and prevalence of nosocomial infection caused by multi-drug resistant strains.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第6期1227-1228,1251,共3页
Chinese Journal of Nosocomiology
关键词
铜绿假单胞菌
多药耐药
医院感染
耐药性
合理用药
Pseudomonas aeruginosa
Multidrug-resistance
Nosocomial infection
Antibiotical resistance
Reasonable use of antibiotics
