摘要
目的探讨周围型肺癌病理、CT表现与血清肿瘤标志物NSE浓度的相关性。方法回顾性分析48例周围型肺癌病理、CT表现与血清肿瘤标志物CA50资料,对比分析病理、CT表现与血清肿瘤标志物CA50关系。结果 30例腺癌CA50浓度为5.90±4.69ng/ml,11例鳞癌CA50浓度为3.44±1.63ng/ml,腺癌与鳞癌血清CA50浓度差异无统计学意义。肺癌的分化程度与血清CA50浓度相关系数r值为-0.117。肺癌有无深分叶征、胸膜凹陷征、瘤体直径≥3cm、毛刺征、支气管气相、增强值≥20Hu、空洞、空泡征、毛玻璃征、钙化及肺门、纵隔淋巴结肿大与其血清CA50浓度差异无统计学意义。肺癌Ki-67抗原阳性百分率与血清CA50浓度之间相关系数r值为0.024。26例p53表达阳性肺癌CA50浓度4.58±2.82ng/ml,22例p53表达阴性肺癌CA50浓度6.41±5.43ng/ml。结论肺癌CT表现、分化程度、Ki-67抗原及p53表达与血清CA50浓度无明显相关性。
Objective To discuss the correlation of pathology, CT features and serum CA50 concentration of peripheral lung cancer. Methods The CT, pathology and CA50 of 48 cases of peripheral lung cancer, confirmed by operation and pathology, were analyed. Results The serum CA50 concentration was 5.90？.69ng/ml（adenocarcinoma）, 3.44？.63ng/ml （squamous carcinoma）. There was no significant difference between the serum CA50 concentration of adenocarcinoma and squamous carcinoma. There was no correlation between the serum CA50 concentration and the tumor differentiation degree in lung cancer.（r= -0.117）. There was no significant difference between lung cancer with deep lobulation sign, diameter3cm, pleural indentation sign, spiculation sign, spinous protuberant sign, increased CT value 20Hu, cavity, calcification or lymph node enlargement of hilar or mediastinal and their serum CA50 concentration. There was no correlation between the percentage of Ki-67 antigen and the serum CA50 concentration in lung cancer（r=0.024）. The serum CA50 concentration was 4.58？.82ng/ml（ p53 positive group）, 6.41？.43ng/ml （p53 negative group）. Conclusion There was no significant difference between tumor differentiation degree , CT features, the expression of Ki-67 antigen or p53 and serum CA50 concentration in peripheral lung cancer.
出处
《中国CT和MRI杂志》
2011年第1期1-3,9,共4页
Chinese Journal of CT and MRI
基金
广州市属高校科技计划项目(61028)
广东省医学科研基金项目(A2004298)
广州医学院博士启动基金项目(0706073)
