摘要
目的:评价川芎嗪结合低分子肝素预防全髋关节置换术后并下肢发深静脉血栓(DVT)的疗效及用药安全性。方法:2006年10月～2008年10月将符合研究标准的患者随机分为空白组、中药组、西药组和中西结合组,随访3个月,根据静脉造影判断DVT的发生情况,根据出凝血情况和肝肾功能评价药物安全性。结果:191例完成随访,53例发生DVT,发生率为27.75%,其中有症状的DVT为23例,发生率为12.05%;空白组18例、中药组15例、西药组14例和中西结合组6例,发生率分别为40.0%、29.41%、29.17%和12.77%;经统计学检验,中西结合组DVT发生率较低。结论:川芎嗪结合低分子肝素预防全髋置换术后DVT具有确切的疗效及良好的安全性,值得临床推广应用。
Objective：To estimate the efficacy and safety of tetramethylpyrazine（TMP） and low molecular weight heparin（LMWH）to prevent deep vein thrombosis（DVT） after total hip arthroplasty（THA）.Methods：All patients were selected from Department of Coxarthropathy,the No.1 Affiliated Hospital of Guangzhou University of Chinese Medicine between October 2006 and October 2008.All patients were randomly divided into control group,chinese medicine group,western medicine group and TCM-WM group;All patients were followed up for 3 months.The incidence of DVT was measured by Venography;the safety of medicine was estimated by coagulation and function of liver and kidney.Results：A total of 191 patients were followed up,53 patients of all 191 patients had DVT,the incidence was 27.75%;23 cases of all 191 patients had clinical symptomatic,the incidence was 12.05%;The incidence were 40.0%、 29.41%、29.17% and 12.77% in group of control（18 cases）、Chinese medicine（15 cases）、western medicine（14 cases） and TCM-WM（6 cases）.The incidence of DVT in TCM-WM group was lower than the other groups,measured by statistical analysis.Conclusion： It is definitely efficacy and safety to prevent DVT after Total Hip Replacement with TMP and LMWH;and it is worthy of clinical application.
出处
《中国中医骨伤科杂志》
CAS
2011年第2期22-25,共4页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
