摘要
目的:以天然高分子壳聚糖为成膜材料制备格列美脲壳聚糖贴剂并研究贴剂的透皮吸收行为。方法:分别以壳聚糖、聚乙烯醇为成膜材料制备格列美脲贴剂。以Wistar大鼠皮肤为渗透屏障,建立HPLC法测定格列美脲贴剂体外透皮速率常数,研究2种不同的成膜材料制备的贴剂透皮吸收的特性。结果:建立的高效液相色谱法测定透皮吸收液中格列美脲含量测定方法简单,格列美脲在0.1～6.0 mg.L-1范围内线性关系良好。大鼠离体皮肤透皮吸收试验结果表明,格列美脲-壳聚糖贴剂渗透系数为6.032μg.cm-22,4 h累积渗透量为185μg。2种贴剂体外经皮渗透曲线方程为Q=kt。结论:以壳聚糖为成膜材料制备的格列美脲贴剂药物释放平稳,符合零级动学特征。
Objective：To prepare glimepiride-chitosan patch and to investigate the activities of transdermal penetration of the patch.Methods：We prepared glimepiride patch with chitosan and polyvinyl alcohol,respectively.An HPLC method was established to determine the activities of transdermal penetration using Wistar rat skin as a skin barrier.Results：The HPLC method was simple in determination of glimepiride concentration and the linear range was over the range of 0.1~6.0 mg·L-1.The in vitro tests showed that the penetration rate was 6.032 μg·cm-2,and cumulative permeation quantity was 185 μg in 24 h for glimepiride-chitosan patch.The cumulative permeation curves of chitosan and polyvinyl alcohol were as follow Q=kt.Conclusion：The glimepiride-chitosan patch steadily releases drug in zero-order kinetics.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2011年第5期456-458,共3页
Chinese Journal of New Drugs
关键词
格列美脲
壳聚糖
聚乙烯醇
贴剂
经皮吸收
glimepiride
chitosan
polyvinyl alcohol
patch
transdermal penetration
