摘要
目的：分析１５３ＳｍＥＤＴＭＰ 治疗转移癌性骨痛的无效病例，以探讨影响治疗效果的可能因素。材料与方法：从３０个月内收集的１２４ 例中，比较有效及无效组的病种、治疗方法、临床情况、年龄、性别等因素，以ＳＡＳ 软件进行成组与多因素分析。结果：治疗无效的２２ 例中男性占９１ ％ （２０ 例） ，肺癌比重大（１３ 例） ，患者的临床情况、治疗方法、全组年龄分布等与治疗效果无明确关系；肿瘤类型和性别与治疗效果相关； 肺癌组的性别和年龄与治疗效果相关。结论：１５３ＳｍＥＤＴＭＰ 治疗时，肺癌，男性，和相对年轻者可能效果差。尽管机制不详，了解这些因素有助于估计疗效。
Purpose:By comparative analysis on painful bony metastases who failed to response to 153 Sm EDTMP palliation, the possible factor controlling therapeutic response was investigated. Materials and Method:22 cases were collected from 124 patients treated with single dose of 153 Sm EDTMP in a multicentre trial. The types of the primaries, general condition of the patients, and previous treatment, etc. were analyzed using SAS software. Results:No positive pelationship could be confirmed between therapeutic response and the parameters like treatment, general condition, and extent of bony involvement. Tumor type (i.e.lung cancer),sex, and probably age, of the patient were the factor noted to relate to response. Conclusion:Although the underlined mechanism is not fully understood, sufferers of lung cancer, especially male patients at relatively younger age, are at higher risk of not responding to 153 Sm EDTMP palliation.
出处
《中国医学影像学杂志》
CSCD
1999年第3期171-174,共4页
Chinese Journal of Medical Imaging
基金
国际原子能机构 区域合作计划资助
关键词
骨转移癌
钐153
EDTMP
止痛
治疗
bone metastases
pain palliation
153 Sm EDTMP
radionuclide therapy
