摘要
紫杉醇依赖于促进微管聚合，抑制微管解聚，诱导肿瘤细胞凋亡，但肿瘤细胞对紫杉醇的耐药性是限制其临床应用的重要因素。一些基础、临床研究均证实β微管蛋白Ⅲ高表达与紫杉醇耐药、预后不良密切相关。
The taxol′ s effect of inducing apoptosis is mainly related to its ability to promote tubulin polymerization and prevent tubulin chain depolarization. Drug resistance is the main restriction factor for clinical usage of taxol. Some basic and clinical studies support that poor response to taxol and poor prognosis are related to overexpression of β tubulin Ⅲ.
出处
《肿瘤研究与临床》
CAS
2011年第2期137-139,共3页
Cancer Research and Clinic
关键词
微管蛋白
紫杉醇
抗药性
肿瘤
Tubulin
Taxol
Drug resistance, neoplasms
