摘要
目的评价脑胶质瘤术后患者三维适形放疗（3DCRT）的预后因素。方法对62例脑胶质瘤术后残留患者行3DCRT，回顾性分析陛别、年龄、肿瘤部位、病理类型、病理分级、手术切除程度、联合化疗、放疗剂量、治疗前Karnofsky评分等因素对预后的影响，用Kaplan—Meier法绘制生存曲线，Log-rank检验法进行单因素分析，COX回归模型进行多因素分析。结果末次随访时间为2009年4月1日，中位随访时问22个月，死亡43例。1、2、3年生存率分别为65．7％、34．2％、20．5％。单因素分析结果显示：年龄（P=0．008）、病理分级（P=0．016）、手术切除程度（P=O．000）、治疗前Kamofsky评分（P=O．018）为重要预后因素。COX多因素分析结果显示：年龄（P=0．031）、手术切除程度（P=0．000）、治疗前Karnofsky评分（P=0．035）为独立预后因素。结论年龄〈40岁、治疗前Karnofsky评分≥70分和肿瘤大部分切除是脑胶质瘤术后3DCRT患者预后较好的独立因素。
Objective To evaluate prognostic factors of patients with cerebral postoperative glioma treated with three-dimensional eonformal radiotherapy （3DCRT）. Methods 62 patients with cerebral glioma who had residual tumor received 3DCRT. Factors such as gender, age, location, of the glioma, pathological type, pathological grade, degree of surgical resection, combined chemotherapy, radiation dose, Karnofsky score before treatment were analyzed to show wether the impact on prognosis, Drawing survival curve with the Kaplan-Meier method, Log-rank test for univariate analysis and multivariate analysis were performed by using COX regression model. Results Last follow-up time was April 1, 2009. Median follow-up was 22 months, 43 patients died. The 1-, 2- and 3-year overall survival rate were 65.7 %, 34.2 % and 20.5 %. In univariate analysis, the survival was related to age （P=0.008）, pathological grade （P=0.016）, degree of surgical resection （P =0.000）, Karnofsky score before treatment （P =0.018）. In COX multivariate modal, age （P =0.031）, degree of surgical resection （P =0.000）, Karnofsky score before treatment （P =0.035） were independent prognostic factors. Conclusion Age 〈40 years, Karnofsky score before treatment 1〉70 and mostly resection are independent factors for predicting better survival of glioma patients.
出处
《肿瘤研究与临床》
CAS
2011年第2期114-116,121,共4页
Cancer Research and Clinic
