摘要
目的:通过对派丽奥(2%盐酸米诺环素软膏)与3%硝酸咪康唑联合应用与单独使用3%硝酸咪康唑治疗义齿性口炎在药物疗效、用药周期以及对真菌和可疑致病菌的清除作用的差异比较,为义齿性口炎的临床局部用药提供参考。方法:选取32例义齿性口炎患者,随机分为实验组(派丽奥+咪康唑组)和对照组(咪康唑组),每组各16人。观察用药半月和1月后义齿性口炎患者的临床指征和口腔黏膜念珠菌及可疑致病菌等微生物学指标的变化。结果:实验组和对照组患者用药后临床症状有所改善,两组间有显著性差异(P<0.05);病损区的白色念珠菌和链球菌数较用药前减少,两组间比较无显著性差异(P>0.05)。治疗半月和1月后实验组患者病损区的放线菌数有明显降低(P<0.01),对照组无明显变化,两组间有显著性差异(P<0.01)。结论:派丽奥与硝酸咪康唑联合应用可有效提高义齿性口炎的治愈率,缩短治疗周期,有效清除真菌和可疑致病菌。
Objective： To compare the difference of drug effect, medication cycle and removal of fungi and putative pathogens, periocline （2% minoeycline ointment） combined with 3% miconazole nitrate or single use of 3% miconazole nitrate were used in treatment of denture stomatitis, and the results were expected to provide reference for local medication in denture stomatitis. Methods： 32 patients diagnosed as denture stomatitis were randomly divided into two groups with 16 patients in each group： experimental group（periocline combined with 3% miconazole nitrate group） and control group（3% miconazole nitrate group）. Clinical indications and microbiology indexes of denture stomatitis patients were analyzed after 7 days and 14 days medication. Results： Clinical indications of two groups were both improved and showed significant difference between two groups （P〈0.05）. Amount of Candida albicans and Streptococcus were obviously decreased after treatment, but there was no significant difference between two groups （P〉0.05）. Amount of actinomycetes was obviously decreased in the experimental group（P〈0.01） after 14 days or one month＇ therapy, but the control group didn＇ t show significant change. There was significant difference between two groups（P〈0.01）. Conclusion： PeriocIine combined with 3% miconazole nitrate can effectively improve the cure rate of denture stomatitis, shorten treatment cycle and remove fungi and putative pathogens.
出处
《中华老年口腔医学杂志》
2010年第5期299-301,共3页
Chinese Journal of Geriatric Dentistry
