摘要
目的探讨3T扩散张量成像(DWI)中表观扩散系数(ADC)值在不同级别星形细胞肿瘤中的差异及其与星形细胞瘤微血管密度和细胞密度的相关性。方法对17例星形细胞肿瘤(其中Ⅰ、Ⅱ级4例,Ⅲ级5例,Ⅳ级8例)行DWI检查,测定不同级别星形细胞肿瘤实性部分ADC值,利用SPSS11.0统计软件包,对不同级别星形细胞肿瘤ADC值进行单因素方差分析,对星形细胞肿瘤ADC与微血管密度和细胞密度行Pearson双变量相关分析。结果 ADC值随肿瘤级别升高有降低趋势,在Ⅰ、Ⅱ与Ⅲ级和Ⅳ级之间的差异均有显著性差异(P值分别为0.008、0.001)。星形细胞肿瘤的ADC值与微血管密度和细胞密度呈负相关(r=-0.516,P=0.013;r=-0.618,P=0.025),具有统计学意义。结论不同级别星形细胞肿瘤ADC值存在明显差异,能够反应肿瘤内部细微结构,ADC值有助于对星形细胞肿瘤进行术前分级评价。
Objective：To analyze the difference of ADC in astrocytomas with different grade and the relationship between microarchitecture and ADC value using DWI at 3T.Materials and Methods：Seventeen patients with astrocytoma（including 5 I/II grade astrocytomas,5 III grade astrocytomas and 8 IV grade astrocytomas） were examined.ADC of each case was obtained.Statistical analysis were performed using SPSS 11.0 package.One-Way ANOVA was used to analyze the difference of ADCs in different grade astrocytomas.Pearson correlations were calculated between ADC value and microarchitecture.Results：ADC tended to reduce from low-to high-grade astrocytomas and the differences between I/II grade and III or IV grade astrocytoma were significant.Significant correlations were revealed between ADC and MVD（r=-0.516,P=0.013） and ADC and cell density（r=-0.618,P=0.025）.Conclusion：ADCs are different between low-and high-grade astrocytoma and can represent the microarchitecture in astrocytoma.DWI is helpful in preoperative grading of astrocytomas.
出处
《磁共振成像》
CAS
2011年第1期47-49,共3页
Chinese Journal of Magnetic Resonance Imaging
关键词
星形细胞肿瘤
表观扩散系数
细胞密度
微血管密度
磁共振成像
Astrocytoma； Apparent diffusion coefficient； Cell density； Microvessel density； Magnetic resonance imaging
