摘要
目的 利用口服葡萄糖耐量试验（ＯＧＴＴ）中体内血糖和胰岛素浓度的改变，探讨血糖和胰岛素对瘦素可能存在的即时和短时效应。方法 ５０ 例Ⅱ型糖尿病和５０ 例非糖尿病个体（ 年龄、性别和体重指数相匹配）做ＯＧＴＴ，测定０、３０、６０、１２０、１８０ 分钟时相的血浆葡萄糖、血清胰岛素和瘦素水平。结果 糖尿病组空腹血清瘦素水平男性为（３．８８ ±０．６４） μｇ／Ｌ，女性为（８．３０ ±１．０６） μｇ／Ｌ ；非糖尿病组男性为（５ ．０１ ±０．６４） μｇ／Ｌ，女性为（１０．４８±１．３０） μｇ／Ｌ ，两组差别无显著性。与非糖尿病组相比，糖尿病组ＯＧＴＴ血糖升高明显，而胰岛素释放曲线呈反应低平，高峰不明显或延迟相。瘦素释放曲线两组均呈下降趋势，糖尿病组这种趋势更为明显。结论 血瘦素水平未曾随着胰岛素浓度的升高而升高，相反表现为昼夜节律性的下降，提示胰岛素促瘦素分泌的效应相对较弱，未能影响瘦素白天下降的趋势。
Objective To investigate the effects of internal change of plasma glucose and serum insulin levels on serum leptin concentrations during oral glucose tolerance test (OGTT) in normal subjects and type Ⅱ diabetics(DM). Methods Plasma glucose, serum insulin and leptin concentrations were measured simultaneously in 50 age, sex and body mass index matched non diabetic(non DM) and 50 DM subjects who were undergoing OGTT. Results The fast serum leptin concentrations were (3.88±0.64) μg/L in DM males and (8.30±1.06) μg/L in DM females. Respectively they were (5.01±0.64) μg/L and (10.48±1.30) μg/L in non DM group. No significant difference was revealed. Comparing with the non DM group, the glucose curve was elevated and the insulin releasing curve was characterized by a low response and a delayed peak in DM group. As for the leptin releasing curve, both groups showed a decreasing trend, which seemed to be more evident in DM group. Conclusion Leptin concentration does not increase with the release of insulin. On the contrary, it shows a diurnal rhythmic descending trend, suggesting that in vivo, the insulin effect on serum leptin concentration is relatively weak and not able to affect the day time descending trend of leptin levels.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1999年第11期740-743,共4页
Chinese Journal of Internal Medicine
基金
美国Rockefeller Foundation
上海第二医科大学自然科学基金
