摘要
目的 探讨蜂胶对阿霉素致小鼠心肌损伤的干预作用.方法 将32只健康昆明小鼠完全随机分为4组,各8只.优选β2环糊精包合蜂胶的最佳工艺,以该蜂胶环糊精包合物为实验药物建立小鼠阿霉素心肌损伤模型,测定血清、心肌的生化指标,并观察心肌结构变化.结果 阿霉素可致小鼠血清肌酸激酶（CK）、乳酸脱氢酶（LDH）活力升高[阿霉素损伤组比正常对照组分别为（4900±270）U/L比（2970±230）U/L与（1080±213）U/L比（835±79）U/L],同时心肌超氧化物化酶（SOD）活力下降[（266±15）U/L比（427±12）U/L]（均P＜0.01）.蜂胶各组CK、LDH活力较阿霉素损伤组明显降低,SOD活力明显升高,其中以蜂胶大剂量组作用明显.结论 蜂胶能够拈抗阿霉素引起的自由基脂质过氧化,从而保护心肌细胞.
Objective To establish myocardial injury in mice model through Adriamycin and to observe the preventive effects of the propolis on adriamycin induced myocardial injury in mice. Methods To establish myocardial injury in mice model through β2 cyclodextrin optimum propolis and experimental drugs of Propolis cyclodextrin and to mensurate many biochemistry targets of blood serum and cardiac muscle, observing the change of Cardiac muscle structure. Results ADR may make creatine kinase（CK）, lactic dehydrogenase （LDH） of mice blood serum high and make SOD of cardiac muscle low. Propolis can reverse the ADR result of this change. The performance is to reduce the CK and LDH of blood serum and raise the SOD of cardiac muscle by dosage relevance. The effect of big group is obvious （ P〈0.01）.Light microscopy also confirmed the protective effect of propolis. Conclusion Propolis can antagonize the free radical lipid peroxidation caused by ADR, protecting myocardial cells.
出处
《中国医药》
2011年第3期264-265,共2页
China Medicine
