摘要
目的:系统评价酒石酸布托啡诺用于术后病人自控静脉镇痛的临床效果及不良反应。方法:计算机检索PubMed、Embase、Cochrane图书馆和CBM(中国生物医学文献数据库),文献检索起止时间均从建库至2008年10月,纳入探讨布托啡诺和吗啡用于病人术后自控静脉镇痛(PCIA)的随机对照试验(RCTs),并逐个进行质量评价和资料提取。统计学评价采用Rev Man 5.0软件。结果:共纳入8个RCT,共502例。3个研究正确描述了随机序列的产生方法,5个研究描述使用盲法,各纳入研究的方法学质量均为B级。结果布托啡诺和吗啡均有满意的临床镇痛效果,布托啡诺能减少恶心呕吐〔RR=0.30,95%CI(0.21,0.42)〕、嗜睡〔RR=0.23,95%CI(0.07,0.79)〕和瘙痒〔RR=0.23,95%CI(0.10,0.54)〕的发生率。结论:现有资料表明,术后PCIA使用布托啡诺和吗啡均能得到满意的临床镇痛效果,但布托啡诺比吗啡能减少恶心呕吐、嗜睡和瘙痒的发生。
Objective： To evaluate the effectiveness of butorphanol and morphine in the patient-controlled intravenous analgesia（PCIA） for postoperative analgesia and the incidence of adverse side effects.Methods： Trials were located through electronic searches of the PubMed,Embase,The Cochrane Library and CBMdisk（from the date of establishment of the databases to October 2008）.Randomized controlled trails（RCTs） of butorphanol and morphine for patient-controlled intravenous analgesia were included.The quality of the trials was critically assessed.RevMan 5.0 software was used for Meta-analysis.Results： Eight RCTs involving 502 patients were included and the quality of all studies was low.The results of Meta-analysis showed that both butorphanol and morphine have the same clinical effects,butorphanol reduced the occurrence of postoperative nausea and vomitting（RR=0.30,95% CI（0.21,0.42））,drowsiness（RR=0.23,95% CI（0.07,0.79））and pruritus（RR=0.23,95% CI（0.10,0.54））.Conclusions： The limited current evidence shows that both butorphanol and morphine have the same clinical effects.Compared with morphine,butorphanol has fewer side effects including nausea,vomitting,drowsiness and pruritus.
出处
《中国疼痛医学杂志》
CAS
CSCD
2011年第2期97-101,共5页
Chinese Journal of Pain Medicine
基金
广西自然科学基金(桂科自0640157)资助课题
关键词
布托啡诺
吗啡
病人自控镇痛
随机对照试验
META分析
Butorphanol
Morphine
Patient-controlled analgesia
Randomized controlled trials
Meta-analysis
