摘要
目的:探讨肌萎缩侧索硬化症功能评分量表(amyotrophic lateral sclerosis functional rating scale revised,ALSFRS-R)及线性变化率(⊿FS)与生存时间相关性。方法:应用2000年世界神经病学联盟修订的El Escorial诊断标准分析64例肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)患者临床资料,予以ALSFRS-R评分及线性变化率(⊿FS),应用Kaplan–Meier法观察从起病至气管切开或死亡的生存曲线,以中位数分组并用Log-rank法检验,两组曲线不同。应用Cox比例风险模型,多因素分析法调整参数:性别、发病年龄、起病病程、用力肺活量(forced vital capacity,FVC)。结果:随访64例ALS患者,失访8人,56人气管切开或死亡,男∶女=2.7∶1。应用Log-rank法检验两组曲线P<0.05,有统计学意义。应用Cox比例风险模型ALSFRS-R评分(HR:0.87,95%CI:0.82～0.93,P<0.01),ALSFRS-R率(HR:5.52,95%CI:3.13～9.71,P<0.01)。结论:ALSFRS-R评分及⊿FS对患者预后有预测价值。
Objective： To study the amyotrophic lateral sclerosis functional rating scale revised（ALSFRS-R） and its progression rate of ALSFRS-R correlation with survival time.Methods：Application of 2000 word Union of Neurology El Escorial diagnostic criteria retrospectively analyzed 64 case of amyotrophic lateral sclerosis clinical date,be ALSFRS-R score and the progress rate（⊿FS）and Kaplan-Meier analysis was used from onset to tracheostomy or death,the median group and Log-rank analysis was used to estimate the difference between two groups.Application of Cox proportional hazards model,adjust the parameters of multi-factor analysis： sex,age,onset duration,forced vital capacity（FVC）.Results：Total 64 ALS patient were followed,8 lost,56 with incision of tracheal or death,M∶F=2.7∶1,the average survival time of 3.5 years.Log-rank analysis of two groups was statistically significant.Application of Cox proportional hazards model ALSFRS-R（HR：0.87,95%CI：0.82-0.93,P 〈 0.01）,⊿FS（HR：5.52,95%CI：3.13-9.71,P 〈 0.01）.Conclusion：ALSFRS-R and ⊿FS predicting the prognosis of patients.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2011年第2期244-247,共4页
Journal of Nanjing Medical University(Natural Sciences)
