摘要
目的探讨仞诊的老年2型糖尿病不同治疗方案对远期预后的影响。方法选取初诊2型糖尿病患者105例，随机分为3组，即三餐前短效胰岛素加睡前中效胰岛素组、每日两次预混胰岛素加口服药组以及单独应用口服降糖药组。其中95例经过平均2—3W的治疗血糖达标，然后改为口服药治疗，观察1年后这些患者的血糖控制情况、胰腺功能、体重变化等。结果胰岛素治疗结束时三组血糖达标率分别是第1组97．1％；第2组94．3％；第3组80％，组间比较第3组与前两组差异有统计学意义，1年后血糖达标率分别是第1组91．2％，第2组为93．9％，第3组为85．0％，第3组与1、2组之间差异仍有统计学意义。前两组在血糖控制上差异无统计学意义。结论初始应用预混胰岛素或多次胰岛素注射两种方式对近期血糖控制和远期血糖控制效果相当，而预混胰岛素联合口服药组比较适合老年患者在门诊中应用。
Objective To study the long-term influence with different therapy means by insulin to newly diagnosed type 2 diabetes. Methods one hundred and five newly diagnosed type 2 diabetes was randomly divided into three groups. The first group was treated by regular insulin three times and humen NPH at bedtime daily. The second group was used twice-daily premixed insulin combined with oral medication. The control group was used oral agents only. Ninety five pa- tients, who reached good blood glucose control after 2-3 weeks treatment, were treated with oral medication. One year treatment later, blood glucose level, pancreas function and weight were measured, respectively. Results After insulin treatment, the ratios of three groups blood glucose control were 97.1%, 94.3% and 80%. One year treatment later, the ratios of blood glucose control were 91.2%, 93.9% and 85%, respectively. Conclusion Short-term insulin treatment can effectively induce long-term good glycemic control in newly type 2 diabetic patients. Twice-daily premixed insulin combined with oral agents is more safety and efficiency for elderly patients.
出处
《老年医学与保健》
CAS
2011年第1期47-48,51,共3页
Geriatrics & Health Care
