摘要
药物诱导性自身免疫性疾病是长期用药引发的一种不良反应,其作用机制因药物种类不同而不同。但最终会因机体丧失对自身抗原的免疫耐受而产生自身抗体。认识原发性和药物诱导性自身免疫反应,将有助于提高对这些疾病机制的理解。并且通过分析药物诱导性自身免疫性疾病的发病机制,为药物不良反应的预防以及临床治疗提供帮助。
Drug-induced autoimmune disease is an adverse effect caused by the long-term use of drug.The mechanisms of actions depend the properties of drugs.The auto-antibodies are produced due to the loss of immune tolerance to the auto-antigens.The understanding of primary and drug-induced autoimmune response helps to improve the study of the pathogenesis of drug-induced autoimmune disease.The analysis of pathogenesis of drug-induced autoimmune disease helps to improve the prevention and treatment of adverse drug reactions.
出处
《医学综述》
2011年第3期441-443,共3页
Medical Recapitulate
