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分别在2型糖尿病降脂、降糖治疗中观察超敏C-反应蛋白水平 被引量：1

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摘要 目的本文通过在2型糖尿病患者使用阿托伐他汀、辛伐他汀和二甲双胍、胰岛素治疗来了解超敏C-反应蛋白(hs-CRP)的含量。方法所有患者在相同基线水平上分成4组,而后分别在阿托伐他汀(A组)和辛伐他汀(B组)3个月治疗下进行不同降脂药对hs-CRP的反应,以及在二甲双胍(C组)和胰岛素(D组)3个月治疗下进行不同降糖药对hs-CRP的影响。结果经3个月治疗后hs-CRP在降脂药比较中显示A组明显低于B组(1.9±0.81mg/Lvs2.4±0.78mg/L,P<0.05),在降糖药比较中显示C组非常明显的低于D组(2.4±0.78mg/Lvs5.58±1.23mg/L,P<0.01)。结论阿托伐他汀较辛伐他汀能更明显的降低hs-CRP,二甲双胍与胰岛素治疗比较,二甲双胍能显著的降低hs-CRP,这是否与内在性减少炎性物质有关,有待进一步调查。
作者 何宇梅
机构地区 云南省第二人民医院干疗科
出处 《中国老年保健医学》 2011年第1期19-20,共2页 Chinese Journal of Geriatric Care
关键词 超敏C-反应蛋白 糖尿病 降脂 降糖
分类号 R587.1 [医药卫生—内分泌]
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参考文献6

  • 1Best LG,Zhang Y,Lee ET,et al.C-reactive protein as a predictor of cardiovascular risk in a population with a high prevalence of diabetes:the Strong Heart Study[J].Circulation,2005,112(9):1289-1295. 被引量：1
  • 2Ridker PM,Cannon CP,Morrow D,et al.C-reactive protein levels and outcomes after statin therapy[J].N Engl J Med,2005,352(1):20-28. 被引量：1
  • 3Ridker PM,Danielson E,Fonseca FA,et al.Reduction in C-reactive protein and LDL-cholesterol and cardiovascular event rates after initiation of rousuvastatin:a prospective study of the JUPITER trial[J].Lancet,2009,373(9670):1175-1182. 被引量：1
  • 4Sathyapalan T,Atkin SL,Kilpatrick ES.Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with type 2 diabetes[J].Diabetes Care,2010,33(9):1948-1950. 被引量：1
  • 5Iliopoulos D,Hirsch HA,Struhl K.An epigenetic switch involving NF-kappa B,Lin 28,Let 7,MicroRNA,and IL-6 links inflammation to cell transformation[J].Cell,2009,139(4):639-706. 被引量：1
  • 6Giovannucci E,Harlan DM,Archer MC,et al.Diabetes and cancer:a consensus report[J].Diabetes Care,2010,33(7):1674-1685. 被引量：1

同被引文献13

  • 1杜九中,于小华,吕建华,邓晖,李双杰,赵刚,张新刚,王时俊,陈瑞珍,杨英珍.溶酶体组织蛋白酶L在小鼠病毒性心肌炎心肌组织中表达及意义[J].临床儿科杂志,2005,23(6):388-390. 被引量：3
  • 2Zhao Z,Geng J, Ge ZM, et al. Efficacy and safety of atorvastatin during early Hospitalization in elderly patients with unstable angina [ J ]. Clinical and Experimental Pharmacology & Physiology, 2009, 36(5 -6) :554 - 558. 被引量：1
  • 3Yun KH, Jeong MH, Oh SK, et at. The beneficial effect of high loading dose of rosuvastatin before pereutaneous coronary interven- tion in patients with acute coronary syndrome [ J ]. International Journal of Cardiology,2009,137(3 ) :246 - 251. 被引量：1
  • 4Wettero J, Nilsson L, Jonasson L, et al. Reduced serum levels of au- toantibedies against monomeric C-reactive protein ( CRP ) in pa- tients with acute coronary syndrome [ J ]. Clinica Chimica acta; In- ternational Journal of Clinical Chemistry ,2009,400 (1 -2) :128 - 131. 被引量：1
  • 5Senturk T, Sarandol E, Gullnlu S, et al. Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes [ J ]. Saudi Medical Journal, 2009,30 (3) :334-339. 被引量：1
  • 6Morrow DA, Wang Y, Cruce K, et al. Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Eval- uation and Infection Therapy:Thrumbolysis in Myocardial Infarc- tion ( PROVE IT-TIM1 22 ) trial [ J ]. American Heart Journal, 2008,155( 1 ) :49 -55. 被引量：1
  • 7Morrow DA, Sabatine MS, Brennan ML, et al. Concurrent evalua- tion of novel cardiac biomarkers in acute coronary syndrome: my- eloperoxidase and soluble CD40 ligand and the risk of recurrent is- chaemic events in TACTICS-TIMI 18 [ J ]. European Heart Jour- nal, 2008,29 ( 9 ) : 1096 - 102. 被引量：1
  • 8Mielniczuk LM, Pfeffer MA, Lewis EF, et al. Estimated glomerular filtration rate, inflammation, and cardiovascular events after an a- cute coronary syndrome [ J ]. American Heart Journal, 2008,155 (4) :725 -731. 被引量：1
  • 9Mega JL, Morrow DA, de Lemos JA, et al. Thrombus precursor pro- tein and clinical outcomes in patients with acute coronary syn- dromes[J]. Journal of the American College of Cardiology,2008, 51 (25) :2422 - 2429. 被引量：1
  • 10Calabro P, Golia E, Yeh ET. CRP and the risk of atherusclerntic e- vents[ J]. Seminars in Immunopathology,2009,31 ( 1 ) :79 - 94. 被引量：1

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中国老年保健医学
2011年 第1期

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