摘要
以线型的羟丙基甲基纤维素(HPMC)和N-异丙基丙烯酰胺(NIPAAm)为原料,制备具有温度敏感性的半互穿网络水凝胶。采用荧光显微镜、红外光谱等对凝胶结构进行表征,并对不同HPMC/NIPAAm配比(W/W)的水凝胶的温度敏感性、溶胀和退溶胀动力学进行了研究。另外,以5-氟尿嘧啶(5-FU)为目标化合物,研究了该凝胶对药物的控释性。结果表明,凝胶在水中的溶胀比随温度的升高迅速降低。在37℃下,pH 7.4的缓冲溶液中,HPMC/NIPAAm配比(W/W)为1/100时凝胶的溶胀比最大,样品PNI-H01对5-FU的释放速度最快。该凝胶体系可以通过调节HPMC的含量及温度来实现药物的控制释放,是一种潜在的口服药物的温敏控释载体。
Using linear HPMC（hydroxypropylmethyl cellulose） and NIPAAm（N-isopropylacrylamide） as raw materials,the temperature-sensitive hydrogels HPMC/PNIPAAm were prepared via the semi-IPN technique.The prepared hydrogels were characterized by Fourier transform infrared（FT-IR） spectroscopy,and their interior morphologies were observed by fluorescent microscope.The thermo-sensitivity,equilibrium swelling ratio and swelling dynamics of the prepared hydrogels were investigated,and the 5-fluorouracil was selected to be used as the model drug for examining the controlled drug release property of the prepared hydrogels.The results show that the swelling ratios of the hydrogels decrease with increasing temperature;and it was found that,the drug release rate of the hydrogel can be controlled by adjusting its HPMC content and the temperature of releasing.In pH 7.4 buffer solution（37℃）,the prepared hydrogel PNI-H01,which was prepared with the weight ratio of HPMC to NIPAAm being 1/100,has the maximal swelling ratio and the fastest drug release rate.The obtained results suggest that the HPMC/PNIPAAm hydrogel would be a potential thermo-sensitive gel for oral drug delivery.
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
2011年第1期123-128,共6页
Journal of Chemical Engineering of Chinese Universities
基金
山东省自然科学重点基金(Y2007C135)资助项目
山东省高等学校科技计划项目(J09LF76)资助项目
