摘要
目的对急性脑梗死(ACI)中符合急性卒中治疗Org10172试验(TOAST)分型患者血清可溶性肿瘤坏死因子相关性凋亡诱导配体(sTRAIL)、骨保护素(OPG)水平进行测定,探讨sTRAIL、OPG在ACI发病中的作用及其临床意义。方法 ACI患者中大动脉粥样硬化型卒中(LAA)17例、小动脉闭塞型卒中(SAO)13例,健康对照14例,分别应用ELISA法测定血清sTRAIL、OPG。结果 ACI患者血清sTRAIL、OPG、空腹血糖(FPG)高于对照组,高密度脂蛋白(HDL)低于对照组;LAA型NIHSS、CSS评分高于SAO,LAA型sTRAIL高于对照组、OPG高于SAO及对照组(P<0.05),统计学有显著性差异,ACI患者血清OPG水平与年龄呈正的线性相关关系。结论 TRAIL、OPG参与了ACI的病理过程,它们在LAA中的作用尤为突出。
Objective Serum soluble tumor necrosis factor related apoptosis-inducing ligand（sTRAIL） and osteoprotegerin（OPG） levels were measured in patients with acute cerebral infarction（ACI） in different subtypes of the Trial of Org 10172 in acute stroke treatment（TOAST）,and their function and Clinical significance in the pathogenesis of ACI were discussed.Methods 17 ACI patients with Large artery atherosclerotic stroke（LAA）,13 cases with small artery occlusion stroke（SAO） and 14 control subjects were included.All their serum levels of sTRAIL and OPG were determined with ELISA method.Results sTRAIL,OPG and fasting plasma glucose（FPG） of ACI patients were higher,HDL was lower than the control group.NIHSS,CSS scores of LAA-type were higher than the SAO-type.Serum sTRAIL of LAA-type was higher than control,and OPG was higher than SAO group and the control with significant differences in Statistics.ACI serum OPG levels showed a positive linear correlation with age.Conclusion TRAIL and OPG participate in the pathological process of ACI,and may play a particularly prominent role in the LAA.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2011年第2期141-144,共4页
Journal of Apoplexy and Nervous Diseases
