摘要
目的:提高对血液肿瘤患者异基因造血干细胞移植(allo-HSCT)后反应性噬血细胞性淋巴组织增生症(HLH)的认识,探讨恰当的治疗方案。方法:报告2例血液肿瘤患者在allo-HSCT后出现反应性HLH的临床表现、实验室检查结果以及治疗和转归特点,结合文献进行分析讨论。结果:2例患者在allo-HSCT后出现发热、血细胞减少、高甘油三酯血症、骨髓中发现噬血细胞现象和高铁蛋白血症,其中例2伴有脾大。2例患者均获益于大剂量糖皮质激素的治疗。结论:反应性HLH是一种非感染性全身炎症反应,在除外感染的情况下应用糖皮质激素疗效佳,但应注意继发性感染的预防和处理。
Objective：To well recognize reactive hemophagocytic lymphohistiocytosis （HLH） in the patients with hematological malignancies after allogeneic stem cell transplantation （allo-HSCT） and explore appropriate treatment.Method：Clinical features,laboratory results,treatment and prognosis of two cases with reactive HLH after allo-HSCT were reported,and relevant literatures were reviewed.Result：Two patients both had fever,pancytopenia,hypertriglyceridemia,hemophagocytes in bone marrow and hyper-ferritinemia. Case 2 also developed splenomegaly. Both of them had favorable response to high-dose glucocorticoid.Conclusion：Reactive HLH is a non-infectious systemic inflammatory disorder,which has excellent response to glucocorticoid if infections can be excluded. However,it is critical to prevent and manage the infections following the treatment with high-dose glucocorticoid.
出处
《临床血液学杂志》
CAS
2011年第1期6-8,共3页
Journal of Clinical Hematology
