摘要
胰腺癌预后极差,相关基础研究一直为学术界研究的热点。胰腺癌干细胞是最有希望改善胰腺癌预后的治疗靶点,于2007年首次分离和鉴定,具有多向分化潜能和自我更新能力,与胰腺癌易于复发、耐药性及侵袭、转移能力相关,针对CSC的靶向治疗已取得部分进展,然而其特异性信号通路研究等众多问题尚待解决。胰腺星状细胞与胰腺癌纤维结缔组织增生关系密切,参与促进胰腺癌的发展及转移,靶向治疗可能有助于提高胰腺癌的综合治疗效果。胰腺癌组织/细胞具有独特的microRNA(miRNA)表达谱,与胰腺癌增殖、凋亡、侵袭、转移及对化疗药物的耐药性相关。动物模型是胰腺癌实验研究中的重要组成部分,正确认识胰腺癌发病过程中的关键分子事件,诱导出与胰腺癌发生密切相关基因的表达将会更好地重现胰腺癌进展过程,为研究其发病机制和探索有效治疗方法提供更佳的研究平台。
Pancreatic cancer is a malignant disease with poor prognosis.Experimental studies of this disease are still the subjects of great concern.Cancer stem cells（CSCs） might be the most promising therapeutic target of pancreatic cancer.Pancreatic cancer stem cells first identified in 2007 are characterized by multilineage differentiation and self-renewal and responsible for the recurrence,resistance to therapy,invasion and metastasis of this malignancy.Therapeutic advancements targeting at CSCs have been reported recently.However many puzzles including the related signal pathways are still unclear.Proliferation and activation of pancreatic stellate cells（PSCs） are essential to the desmoplastic reaction of pancreatic cancer.PSCs are involved in the progression and metastasis of pancreatic cancer.Targeting therapy based on PSCs might be helpful to improve the prognosis of pancreatic cancer.Recent research showed that microRNAs（miRNAs） are abnormally expressed in pancreatic cancer tissue or cell lines.The abnormal expression of miRNAs may participate in the proliferation,apoptosis,invasion,metastasis and chemotherapy-resistance of pancreatic cancer.Animal models of pancreatic cancer are important for the research into this disease.An ideal pancreatic cancer animal model based on the progressional mutations of cancer related genes would be effective in exploring the tumorigenesis and therapy of pancreatic cancer.
出处
《中华普外科手术学杂志（电子版）》
2011年第1期9-14,共6页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
基金
国家自然科学基金资助项目(30772120
30972897)
关键词
胰腺肿瘤
肿瘤干细胞
胰腺星状细胞
微RNAS
模型
动物
Pancreatic cancer
Neoplastic stem cells
Pancreatic stellate cell
Micro RNAs
Models
animal
